Nanoparticle-based delivery systems for vaccines

R Bezbaruah, VP Chavda, L Nongrang, S Alom… - Vaccines, 2022 - mdpi.com
Vaccination is still the most cost-effective way to combat infectious illnesses. Conventional
vaccinations may have low immunogenicity and, in most situations, only provide partial …

Lipid nanoparticles: Different preparation techniques, characterization, hurdles, and strategies for the production of solid lipid nanoparticles and nanostructured lipid …

P Ganesan, D Narayanasamy - Sustainable Chemistry and Pharmacy, 2017 - Elsevier
The bioavailability of an orally administered drug primarily depends on its solubility in the
GIT and its permeability across cell membranes. Also, a drug in solution form is preferred for …

Lipid-based nanoparticles for drug delivery systems

S Samimi, N Maghsoudnia, RB Eftekhari… - … and biology of …, 2019 - Elsevier
Solid lipid nanoparticles (SLNs) and nanostructured lipid carriers (NLCs) have opened new
horizons in the pharmaceutical industry since they play a fundamental role in the field of …

Comprehensive analysis of liposome formulation parameters and their influence on encapsulation, stability and drug release in glibenclamide liposomes

S Maritim, P Boulas, Y Lin - International journal of pharmaceutics, 2021 - Elsevier
An understanding of the factors that affect liposome size, drug loading, stability and drug
release is critical for the rational design of liposomes with desired pharmacokinetics and …

Oral druggable space beyond the rule of 5: insights from drugs and clinical candidates

BC Doak, B Over, F Giordanetto, J Kihlberg - Chemistry & biology, 2014 - cell.com
The rule of 5 (Ro5) is a set of in silico guidelines applied to drug discovery to prioritize
compounds with an increased likelihood of high oral absorption. It has been influential in …

Biodegradable polymer nanogels for drug/nucleic acid delivery

Y Li, D Maciel, J Rodrigues, X Shi, H Tomás - Chemical reviews, 2015 - ACS Publications
Despite the extensive research on therapeutic delivery, many problems still exist on how to
develop a proper platform (a carrier) that can deliver drugs/nucleic acids to specific sites of …

[HTML][HTML] Nanovaccines: a game changing approach in the fight against infectious diseases

MAH Abusalah, H Chopra, A Sharma… - Biomedicine & …, 2023 - Elsevier
The field of nanotechnology has revolutionised global attempts to prevent, treat, and
eradicate infectious diseases in the foreseen future. Nanovaccines have proven to be a …

Cell-based drug delivery systems and their in vivo fate

L Yang, Y Yang, Y Chen, Y Xu, J Peng - Advanced Drug Delivery Reviews, 2022 - Elsevier
Cell-based drug delivery systems (DDSs) have received attention recently because of their
unique biological properties and self-powered functions, such as excellent biocompatibility …

Mechanisms of drug release from advanced drug formulations such as polymeric-based drug-delivery systems and lipid nanoparticles

GH Son, BJ Lee, CW Cho - Journal of Pharmaceutical Investigation, 2017 - Springer
Drug release from a polymeric nanocarrier is affected by several factors including the sort of
composition (drug, polymer, and excipient), the ratio of composition, physical or chemical …

Supersaturating drug delivery systems: the answer to solubility-limited oral bioavailability?

J Brouwers, ME Brewster, P Augustijns - Journal of pharmaceutical …, 2009 - Elsevier
Contemporary pharmaceutical pipelines are often highly populated with poorly water-
soluble drug candidates necessitating novel formulation technologies to provide dosage …