A grand challenge in the field of structural biology is to design and engineer proteins that
exhibit targeted functions. Although much success on this front has been achieved, design …

Topology is at the very heart of chemistry. This stems from the fact that chemical thought,
since its prescientific alchemic origins, focused on the mutual relations between different …

The proliferating cell nuclear antigen (PCNA) has emerged as a promising candidate for the
development of novel cancer therapeutics. PCNA is a nononcogenic mediator of DNA …

Engineering proteins for thermostability is an exciting and challenging field since it is critical
for broadening the industrial use of recombinant proteins. Thermostability of proteins arises …

The human immunodeficiency virus interacts with the cluster of differentiation 4 receptors
and one of the two chemokine receptors (CCR5 and CXCR4) to gain entry in human cells …

Conformational heterogeneity is emerging as a defining characteristic of enzyme function.
However, understanding the role of protein conformations requires their thermodynamic and …

The phenotypic effect of an allele at one genetic site may depend on alleles at other sites, a
phenomenon known as epistasis. Epistasis can profoundly influence the process of …

Protein pharmaceuticals have become a significant class of marketed drug products and are
expected to grow steadily over the next decade. Development of a commercial protein …

Aurora-A is a novel therapeutic target that belongs to the serine/threonine kinase family of
proteins. Several cancers are associated with gene amplification or over-expression of …

It is well recognized that protein product development is far more challenging than that for
small‐molecule drugs. The major challenges include inherent sensitivity to different types of …