BACKGROUND Progesterone is a key hormonal regulator of the female reproductive
system. It plays a major role to prepare the uterus for implantation and in the establishment …

OBJECTIVE: To determine whether the use of vaginal progesterone in asymptomatic women
with a sonographic short cervix (≤ 25 mm) in the midtrimester reduces the risk of preterm …

Objectives Women with a sonographic short cervix in the mid‐trimester are at increased risk
for preterm delivery. This study was undertaken to determine the efficacy and safety of using …

Oxytocin is a nonapeptide hormone that has a central role in the regulation of parturition and
lactation. In this review, we address oxytocin receptor (OTR) signalling and its role in the …

Background Preterm birth is a major complication of pregnancy associated with perinatal
mortality and morbidity. Progesterone for the prevention of preterm labour has been …

Preterm birth is associated with high rates of infant mortality and morbidity. This review
emphasizes that the onset of labor entails a molecular collaboration between the mother …

Rapid, progestin actions initiated at the cell surface that are often nongenomic have been
described in a variety of reproductive tissues, but until recently the identities of the …

The mechanisms involved in human pregnancy maintenance and parturition are highly
complex and involve mother, fetus and placenta. The “final common pathway” to delivery is …

Throughout most of pregnancy, uterine quiescence is maintained by increased
progesterone receptor (PR) transcriptional activity, whereas spontaneous labor is …

Mechanisms underlying the initiation of parturition remain unclear. Throughout most of
pregnancy, uterine quiescence is maintained by elevated progesterone acting through …