Aging is a gradual and irreversible pathophysiological process. It presents with declines in
tissue and cell functions and significant increases in the risks of various aging-related …

Parkinson's disease (PD) is clinically, pathologically, and genetically heterogeneous,
resisting distillation to a single, cohesive disorder. Instead, each affected individual develops …

Biological aging of human organ systems reflects the interplay of age, chronic disease,
lifestyle and genetic risk. Using longitudinal brain imaging and physiological phenotypes …

Alzheimer's disease and related dementias (ADRD) are among the top contributors to
disability and mortality in later life. As with many chronic conditions, aging is the single most …

Alzheimer's disease (AD) is a disorder that causes degeneration of the cells in the brain and
it is the main cause of dementia, which is characterized by a decline in thinking and …

A hallmark of nervous system aging is a decline of white matter volume and function, but the
underlying mechanisms leading to white matter pathology are unknown. In the present …

ApoE is the major lipid and cholesterol carrier in the CNS. There are three major human
polymorphisms, apoE2, apoE3, and apoE4, and the genetic expression of APOE4 is one of …

Quercetin, a naturally non-toxic flavonoid within the safe dose range with antioxidant, anti-
apoptotic and anti-inflammatory properties, plays an important role in the treatment of aging …

Aggregation of specific proteins are histopathological hallmarks of several
neurodegenerative diseases, such as, Amyloid β (Aβ) plaques and tau neurofibrillary …

Patients with Alzheimer's disease (AD) present with both extracellular amyloid-β (Aβ)
plaques and intracellular tau-containing neurofibrillary tangles in the brain. For many years …