Type 2 diabetes mellitus (T2DM) remains one of the most problematic and economic
consumer disorders worldwide, with growing prevalence and incidence. Over the last years …

The past decade has been characterized by tremendous progress in the field of the gut
microbiota and its impact on host metabolism. Although numerous studies show a strong …

For the last 20 years, researchers have focused their intention on the impact of gut
microbiota in healthy and pathological conditions. This year (2021), more than 25,000 …

Enteric neuronal degeneration, as seen in inflammatory bowel disease, obesity, and
diabetes, can lead to gastrointestinal dysmotility. Pyroptosis is a novel form of programmed …

Neurodegeneration of the central and enteric nervous systems is a common feature of aging
and aging-related diseases, and is accelerated in individuals with metabolic dysfunction …

Key points A high‐fat diet (60% kcal from fat) is associated with motility disorders inducing
constipation and loss of nitrergic myenteric neurons in the proximal colon. Gut microbiota …

Diabetes, commonly known for its metabolic effects, also critically affects the enteric nervous
system (ENS), which is essential in regulating gastrointestinal (GI) motility, secretion, and …

Adolescence is a critical period of development. It is very likely that there is significant
maturation of the enteric nervous system (ENS) of the gut during this stage of life, especially …

Of all the organ systems in the body, the gastrointestinal tract is the most complicated in
terms of the numbers of structures involved, each with different functions, and the numbers …

Systemic inflammation is a key contributor to the onset and progression of several obesity‐
associated diseases and is thought to predominantly arise from the hyperplasia and …