Mammalian retinal degenerations initiated by gene defects in rods, cones or the retinal
pigmented epithelium (RPE) often trigger loss of the sensory retina, effectively leaving the …

▪ Abstract The neurons of the cochlear ganglion transmit acoustic information between the
inner ear and the brain. These placodally derived neurons must produce a topographically …

The external ear or pinna (auricle) collects sound, which passes along the external auditory
canal to the eardrum (tympanic membrane)(Fig. 2.1). The middle ear (tympanum) is a cavity …

Cochlear inner hair cells (IHCs) release neurotransmitter onto afferent auditory nerve fibers
in response to sound stimulation. During early development, afferent synaptic transmission …

At specific stages of development, nerve and muscle cells generate spontaneous electrical
activity that is required for normal maturation of intrinsic excitability and synaptic connectivity …

Neurons completely transform how they regulate cell death over the course of their lifetimes.
Developing neurons freely activate cell death pathways to fine-tune the number of neurons …

Neurons in the developing auditory system fire bursts of action potentials before the onset of
hearing. This spontaneous activity promotes the survival and maturation of auditory neurons …

Developmental changes in electrophysiological membrane properties of mouse cochlear
inner hair cells (IHCs) were studied from just after terminal differentiation up to functional …

Cochlear inner hair cells (IHCs), the mammalian auditory sensory cells, encode acoustic
signals with high fidelity by Graded variations of their membrane potential trigger rapid and …

A profound sensorineural hearing loss induces significant pathological and atrophic
changes within the cochlea and central auditory pathway. We describe these deafness …