UV-induced DNA damage plays a key role in the initiation phase of skin cancer. When left
unrepaired or when damaged cells are not eliminated by apoptosis, DNA lesions express …

Sequencing complete tumor genomes and exomes has sparked the cancer field's interest in
mutation signatures for identifying the tumor's carcinogen. This review and meta‐analysis …

Ultraviolet (UV) light induces specific mutations in the cellular and skin genome such as UV-
signature and triplet mutations, the mechanism of which has been thought to involve …

In this survey, emphasis was placed on the main photoreactions of nucleic acid components,
involving both direct and indirect effects. The main UVB-and UVA-induced DNA …

Bipyrimidine photoproducts induced in DNA by UVB radiation include cyclobutane dimers,(6-
4) photoproducts, and their related Dewar valence isomers. Even though these lesions have …

Pterygium is a disease of the ocular surface that is associated with chronic UV exposure and
is characterized by proliferation, inflammatory infiltrates, fibrosis, angiogenesis and …

Methylcytosine in DNA is genetically unstable. Methylated CpG (mCpG) sequences
frequently undergo mutation resulting in a general depletion of this dinucleotide sequence in …

Photochemoprevention has become an important armamentarium in the fight against
ultraviolet radiation (UVR)‐induced damage to the skin. Among many UVR‐induced …

Transgenic mutation assays were developed to detect gene mutations in multiple organs of
mice or rats. The assays permit (1) quantitative measurements of mutation frequencies in all …

UVB radiation is the most mutagenic component of the UV spectrum that reaches the earth's
surface and causes the development of DNA damage in the form of cyclobutane pyrimidine …