Tyrosinase is a multi-copper enzyme which is widely distributed in different organisms and
plays an important role in the melanogenesis and enzymatic browning. Therefore, its …

Tyrosinase plays a pivotal role in the synthesis of melanin pigment synthesis on skin utilizing
tyrosine as a substrate. Melanin is responsible for the protection against harmful ultraviolet …

Hyperpigmentation is a common and distressing dermatologic condition. Since tyrosinase
(TYR) plays an essential role in melanogenesis, its inhibition is considered a logical …

In the modern scenario, thiazolidinone scaffold has emerged as a very potent scaffold as per
its clinical significance concerned. It has attracted the keen interest of the researchers due to …

Tyrosinase (EC 1.14. 18.1), a copper‐containing enzyme, can cause enzymatic browning in
raw fruits, vegetables, and beverages. Browning is an undesirable reaction that is …

Tyrosinase and its related proteins are responsible for pigmentation disorders, and inhibiting
tyrosinase is an established strategy to treat hyperpigmentation. The carbonyl scaffolds can …

In continuing our search for novel tyrosinase inhibitors, a series of 5-(substituted
benzylidene) thiazolidine-2, 4-diones were rationally designed and synthesized, and their …

Three structurally similar aromatic heterocyclic compounds 2-thiophenecarboxaldehyde (a),
2-furaldehyde (b), 2-pyrrolecarboxaldehyde (c) were chosen and a series of their …

Abstract A new compound, 9-dihydroxyl-2'-O-(Z)-cinnamoyl-7-methoxy-aloesin (1), and eight
known compounds (2–9) were isolated from Aloe vera. Their structures were elucidated …

Due to the fact that tyrosinase is responsible for biosynthesis and regulation of melanins and
browning food products, tyrosinase inhibitors can be favorable agents in cosmetics and …