The ins-and-outs of exosome biogenesis, secretion, and internalization
Exosomes are specialized cargo delivery vesicles secreted from cells by fusion of
multivesicular bodies (MVBs) with the plasma membrane (PM). While the function of …
multivesicular bodies (MVBs) with the plasma membrane (PM). While the function of …
Nanoparticle entry into cells; the cell biology weak link
G Griffiths, J Gruenberg, M Marsh, J Wohlmann… - Advanced Drug Delivery …, 2022 - Elsevier
Nanoparticles (NP) are attractive options for the therapeutic delivery of active
pharmaceutical drugs, proteins and nucleic acids into cells, tissues and organs. Research …
pharmaceutical drugs, proteins and nucleic acids into cells, tissues and organs. Research …
Endothelial cell CD36 regulates membrane ceramide formation, exosome fatty acid transfer and circulating fatty acid levels
Endothelial cell (EC) CD36 controls tissue fatty acid (FA) uptake. Here we examine how ECs
transfer FAs. FA interaction with apical membrane CD36 induces Src phosphorylation of …
transfer FAs. FA interaction with apical membrane CD36 induces Src phosphorylation of …
Caveolin-1 dolines form a distinct and rapid caveolae-independent mechanoadaptation system
In response to different types and intensities of mechanical force, cells modulate their
physical properties and adapt their plasma membrane (PM). Caveolae are PM nano …
physical properties and adapt their plasma membrane (PM). Caveolae are PM nano …
Caveolae: Mechanosensing and mechanotransduction devices linking membrane trafficking to mechanoadaptation
MA Del Pozo, FN Lolo, A Echarri - Current opinion in cell biology, 2021 - Elsevier
Mechanical forces (extracellular matrix stiffness, vascular shear stress, and muscle
stretching) reaching the plasma membrane (PM) determine cell behavior. Caveolae are PM …
stretching) reaching the plasma membrane (PM) determine cell behavior. Caveolae are PM …
Energy and dynamics of caveolae trafficking
C Matthaeus, JW Taraska - Frontiers in Cell and Developmental …, 2021 - frontiersin.org
Caveolae are 70–100 nm diameter plasma membrane invaginations found in abundance in
adipocytes, endothelial cells, myocytes, and fibroblasts. Their bulb-shaped membrane …
adipocytes, endothelial cells, myocytes, and fibroblasts. Their bulb-shaped membrane …
The molecular organization of differentially curved caveolae indicates bendable structural units at the plasma membrane
Caveolae are small coated plasma membrane invaginations with diverse functions.
Caveolae undergo curvature changes. Yet, it is unclear which proteins regulate this process …
Caveolae undergo curvature changes. Yet, it is unclear which proteins regulate this process …
Caveolae mechanotransduction at the interface between cytoskeleton and extracellular matrix
L Sotodosos-Alonso, M Pulgarín-Alfaro, MA Del Pozo - Cells, 2023 - mdpi.com
The plasma membrane (PM) is subjected to multiple mechanical forces, and it must adapt
and respond to them. PM invaginations named caveolae, with a specific protein and lipid …
and respond to them. PM invaginations named caveolae, with a specific protein and lipid …
Caveolae promote successful abscission by controlling intercellular bridge tension during cytokinesis
During cytokinesis, the intercellular bridge (ICB) connecting the daughter cells experiences
pulling forces, which delay abscission by preventing the assembly of the ESCRT scission …
pulling forces, which delay abscission by preventing the assembly of the ESCRT scission …
Key phases in the formation of caveolae
Caveolae are abundant plasma membrane pits formed by the coordinated action of
peripheral and integral membrane proteins and membrane lipids. Here, we discuss recent …
peripheral and integral membrane proteins and membrane lipids. Here, we discuss recent …