Adding a new separation dimension to MS and LC–MS: what is the utility of ion mobility spectrometry?

V d'Atri, T Causon, O Hernandez‐Alba… - Journal of separation …, 2018 - Wiley Online Library
Ion mobility spectrometry is an analytical technique known for more than 100 years, which
entails separating ions in the gas phase based on their size, shape, and charge. While ion …

Advances and perspectives in chemical isotope labeling-based mass spectrometry methods for metabolome and exposome analysis

S Gao, X Zhou, M Yue, S Zhu, Q Liu, XE Zhao - TrAC Trends in Analytical …, 2023 - Elsevier
Metabolomics and exposomics are important in the studies of human health and diseases.
Chemical isotope labeling (CIL) combined with mass spectrometry (MS) can not only …

Metabolomics and lipidomics using traveling-wave ion mobility mass spectrometry

G Paglia, G Astarita - Nature protocols, 2017 - nature.com
Metabolomics and lipidomics aim to profile the wide range of metabolites and lipids that are
present in biological samples. Recently, ion mobility spectrometry (IMS) has been used to …

On-tissue derivatization via electrospray deposition for matrix-assisted laser desorption/ionization mass spectrometry imaging of endogenous fatty acids in rat brain …

Q Wu, TJ Comi, B Li, SS Rubakhin… - Analytical …, 2016 - ACS Publications
Matrix-assisted laser desorption/ionization (MALDI) mass spectrometry imaging (MSI) is
used for the multiplex detection and characterization of diverse analytes over a wide mass …

Options of the main derivatization approaches for analytical ESI and MALDI mass spectrometry

VG Zaikin, RS Borisov - Critical Reviews in Analytical Chemistry, 2022 - Taylor & Francis
The inclusion of preliminary chemical labeling (derivatization) in the analysis process by
such powerful and widespread methods as electrospray ionization (ESI) and matrix-assisted …

Isotope-coded ESI-enhancing derivatization reagents for differential analysis, quantification and profiling of metabolites in biological samples by LC/MS: A review

T Higashi, S Ogawa - Journal of pharmaceutical and biomedical analysis, 2016 - Elsevier
The analysis of the qualitative and quantitative changes of metabolites in body fluids and
tissues yields valuable information for the diagnosis, pathological analysis and treatment of …

Mass spectrometry-based single-cell lipidomics: Advancements, challenges, and the path forward

CE Randolph, P Manchanda, H Arora, S Iyer… - TrAC Trends in …, 2023 - Elsevier
In the past decade, lipidomics, now recognized as standalone subdiscipline of
metabolomics, has gained considerable attention. Due to its sensitivity and unparalleled …

Lipidomics in food science

H Chen, F Wei, X Dong, J Xiang, S Quek… - Current Opinion in Food …, 2017 - Elsevier
Highlights•Lipidomics approaches, which enable large-scale and comprehensive studies of
lipids, have been used in food science research.•To achieve the potential of understanding …

Recent progress in the analysis of unsaturated fatty acids in biological samples by chemical derivatization-based chromatography-mass spectrometry methods

C Chen, R Li, H Wu - Journal of Chromatography B, 2023 - Elsevier
Unsaturated fatty acids (UFAs) are essential fatty acids that execute various biological
functions in the human body. Therefore, the qualitative and quantitative analysis of UFAs in …

[HTML][HTML] Structural analysis of natural products

J Přichystal, KA Schug, K Lemr, J Novak, V Havlíček - 2016 - ACS Publications
Current mass spectrometry, nuclear magnetic resonance spectroscopy, and X-ray diffraction
are presented as structure elucidation tools for analytical chemistry of natural products …