Here, we addressed the pharmacology and toxicology of synthetic organoselenium
compounds and some naturally occurring organoselenium amino acids. The use of …

Cis-diamminedichloridoplatinum (II)(cisplatin) is a chemotherapeutic drug currently
prescribed for the treatment of many types of human cancer, but its use is associated with …

Apoptotic cell death is implicated in both physiological and pathological processes. Since
many types of cancerous cells intrinsically evade apoptotic elimination, induction of …

Background Mangiferin is a polyphenolic xanthonoid with remarkable antioxidant activity.
Oxidative stress plays the key role in tert-butyl hydroperoxide (tBHP) induced renal cell …

Cisplatin is a widely used chemotherapeutic drug for the treatment of various cancers.
However, the ototoxicity severely limited its maximum dose. The present study was designed …

Aminoglycoside, a medicinal category of antibiotics, are used in treatment of Gram-negative
bacterial infections. Although they are the most widely-used antibiotics due to their high …

Deregulation of apoptosis is associated with various pathologies, such as
neurodegenerative disorders at one end of the spectrum and cancer at the other end …

Hearing loss is a severe high unmet need condition affecting more than 1.5 billion people
globally. There are no licensed medicines for the prevention, treatment or restoration of …

MicroRNA-21 (miR-21) has been found to be upregulated in keloid tissue and to affect the
proliferation and apoptosis of keloid fibroblasts; however, the possible mechanisms remain …

The protein apoptotic protease activating factor 1 (Apaf1) is the central component of the
apoptosome, a multiprotein complex that activates procaspase-9 after cytochrome c release …