Hsp90 is a dimeric molecular chaperone required for the activation and stabilization of
numerous client proteins many of which are involved in essential cellular processes like …

Cystic fibrosis (CF) is the most common life-threatening monogenic disease afflicting
Caucasian people. It affects the respiratory, gastrointestinal, glandular and reproductive …

An improved understanding of the cystic fibrosis (CF) transmembrane conductance regulator
(CFTR) protein structure and the consequences of CFTR gene mutations have allowed the …

Nitric oxide participates in cellular signal transduction largely through S-nitrosylation of
allosteric and active-site cysteine thiols within proteins, forming S-nitroso-proteins (SNO …

Cystic fibrosis (CF) is a monogenic autosomal recessive disorder that affects about 70 000
people worldwide. The clinical manifestations of the disease are caused by defects in the …

Neurodegenerative disorders like Alzheimer's disease and Parkinson's disease are
characterized by progressive degeneration of synapses and neurons. Accumulation of …

Covering: 2005 to 2013In this review recent progress in the development of heat shock
proteins (Hsp90) in oncogenesis is illuminated. Particular emphasis is put on inhibitors such …

Cystic fibrosis (CF) is a lethal genetic disease caused by mutations in the chloride ion
channel cystic fibrosis transmembrane conductance regulator (CFTR). Class-II mutants of …

Mutations of the CFTR gene cause cystic fibrosis (CF), the most common recessive
monogenic disease worldwide. These mutations alter the synthesis, processing, function, or …

Etiological therapies aim at repairing the underlying cause of cystic fibrosis (CF), which is
the functional defect of the cystic fibrosis transmembrane conductance regulator (CFTR) …