RNA molecules start assembling into ribonucleoprotein (RNP) complexes during
transcription. Dynamic RNP assembly, largely directed by cis-acting elements on the RNA …

The ability of living systems to adapt to changing conditions originates from their capacity to
change their molecular constitution. This is achieved by multiple mechanisms that modulate …

Proteins and RNA functionally and physically intersect in multiple biological processes,
however, currently no universal method is available to purify protein-RNA complexes. Here …

The RNA exosome complex is the most versatile RNA-degradation machine in eukaryotes.
The exosome has a central role in several aspects of RNA biogenesis, including RNA …

Numerous long intervening noncoding RNAs (lincRNAs) are generated from the mammalian
genome by RNA polymerase II (Pol II) transcription. Although multiple functions have been …

The eukaryotic RNA exosome is an essential and conserved protein complex that can
degrade or process RNA substrates in the 3′-to-5′ direction. Since its discovery nearly …

During transcription, the nascent RNA can invade the DNA template, forming extended RNA-
DNA duplexes (R-loops). Here we employ ChIP-seq in strains expressing or lacking RNase …

The multisubunit RNA exosome complex is a major ribonuclease of eukaryotic cells that
participates in the processing, quality control and degradation of virtually all classes of RNA …

Eukaryotic genomes generate a heterogeneous ensemble of mRNAs and long noncoding
RNAs (lncRNAs). LncRNAs and mRNAs are both transcribed by Pol II and acquire 5′ caps …

The exosome is a complex involved in the maturation of rRNA and sn-snoRNA, in the
degradation of short-lived noncoding RNAs, and in the quality control of RNAs produced in …