Heterogeneity of small vessel disease: a systematic review of MRI and histopathology correlations

AA Gouw, A Seewann, WM Van Der Flier… - Journal of Neurology …, 2011 - jnnp.bmj.com
Background White matter hyperintensities (WMH), lacunes and microbleeds are regarded as
typical MRI expressions of cerebral small vessel disease (SVD) and they are highly …

β-Amyloid, blood vessels, and brain function

EE Smith, SM Greenberg - Stroke, 2009 - Am Heart Assoc
Cerebrovascular disease and Alzheimer disease are common diseases of aging and
frequently coexist in the same brain. Accumulating evidence suggests that the presence of …

White matter lesions in an unselected cohort of the elderly: molecular pathology suggests origin from chronic hypoperfusion injury

MS Fernando, JE Simpson, F Matthews, C Brayne… - Stroke, 2006 - Am Heart Assoc
Background and Purpose—“Incidental” MRI white matter (WM) lesions, comprising
periventricular lesions (PVLs) and deep subcortical lesions (DSCLs), are common in the …

Imaging of amyloid burden and distribution in cerebral amyloid angiopathy

KA Johnson, M Gregas, JA Becker… - Annals of Neurology …, 2007 - Wiley Online Library
Objective Cerebrovascular deposition of β‐amyloid (cerebral amyloid angiopathy [CAA]) is a
major cause of hemorrhagic stroke and a likely contributor to vascular cognitive impairment …

Hemorrhage burden predicts recurrent intracerebral hemorrhage after lobar hemorrhage

SM Greenberg, JA Eng, MM Ning, EE Smith, J Rosand - Stroke, 2004 - Am Heart Assoc
Background and Purpose—Small asymptomatic cerebral hemorrhages detectable by
gradient-echo MRI are common in patients with intracerebral hemorrhage (ICH), particularly …

Clinical manifestations of cerebral amyloid angiopathy–related inflammation

JA Eng, MP Frosch, K Choi, GW Rebeck… - Annals of Neurology …, 2004 - Wiley Online Library
To explore the clinical effects of inflammation associated with vascular deposits of the
amyloid β peptide (Aβ), we analyzed 42 consecutive patients with pathologically diagnosed …

White matter lesion progression, brain atrophy, and cognitive decline: the Austrian stroke prevention study

R Schmidt, S Ropele, C Enzinger… - Annals of Neurology …, 2005 - Wiley Online Library
White matter lesions progress over time, but the clinical consequences are widely unknown.
Three‐hundred twenty‐nine elderly community‐dwelling volunteers underwent serial …

Type 2 diabetes and cognitive impairment: linking mechanisms

JA Luchsinger - Journal of Alzheimer's Disease, 2012 - content.iospress.com
This manuscript provides a brief review of current concepts in the mechanisms potentially
linking type-2-diabetes (T2D) with cognitive impairment. Existing epidemiologic studies …

Spatial relation between microbleeds and amyloid deposits in amyloid angiopathy

GA Dierksen, ME Skehan, MA Khan, J Jeng… - Annals of …, 2010 - Wiley Online Library
Advanced cerebrovascular β‐amyloid deposition (cerebral amyloid angiopathy, CAA) is
associated with cerebral microbleeds, but the precise relationship between CAA burden and …

Ischemic brain injury in cerebral amyloid angiopathy

YD Reijmer, SJ Van Veluw… - Journal of Cerebral …, 2016 - journals.sagepub.com
Cerebral amyloid angiopathy (CAA) is a common form of cerebral small vessel disease and
an important risk factor for intracerebral hemorrhage and cognitive impairment. While the …