An overview of vaccine adjuvants: current evidence and future perspectives
Vaccinations are one of the most important preventive tools against infectious diseases.
Over time, many different types of vaccines have been developed concerning the antigen …
Over time, many different types of vaccines have been developed concerning the antigen …
Effect of vaccine administration modality on immunogenicity and efficacy
L Zhang, W Wang, S Wang - Expert review of vaccines, 2015 - Taylor & Francis
The many factors impacting the efficacy of a vaccine can be broadly divided into three
categories: features of the vaccine itself, including immunogen design, vaccine type …
categories: features of the vaccine itself, including immunogen design, vaccine type …
Anti–PD-1 antitumor immunity is enhanced by local and abrogated by systemic chemotherapy in GBM
The immunosuppressive effects of chemotherapy present a challenge for designing effective
cancer immunotherapy strategies. We hypothesized that although systemic chemotherapy …
cancer immunotherapy strategies. We hypothesized that although systemic chemotherapy …
A systematic review on poly (I: C) and poly-ICLC in glioblastoma: adjuvants coordinating the unlocking of immunotherapy
J De Waele, T Verhezen, S van der Heijden… - Journal of Experimental …, 2021 - Springer
Immunotherapy is currently under intensive investigation as a potential breakthrough
treatment option for glioblastoma. Given the anatomical and immunological complexities …
treatment option for glioblastoma. Given the anatomical and immunological complexities …
Vaccine adjuvant uses of poly-IC and derivatives
KAO Martins, S Bavari, AM Salazar - Expert review of vaccines, 2015 - Taylor & Francis
Pathogen-associated molecular patterns (PAMPs) are stand-alone immunomodulators or
'danger signals,'that are increasingly recognized as critical components of many modern …
'danger signals,'that are increasingly recognized as critical components of many modern …
Exploration of pattern recognition receptor agonists as candidate adjuvants
GH Ong, BSX Lian, T Kawasaki… - Frontiers in cellular and …, 2021 - frontiersin.org
Adjuvants are used to maximize the potency of vaccines by enhancing immune reactions.
Components of adjuvants include pathogen-associated molecular patterns (PAMPs) and …
Components of adjuvants include pathogen-associated molecular patterns (PAMPs) and …
Immunotherapy advances for glioblastoma
DA Reardon, G Freeman, C Wu, EA Chiocca… - Neuro …, 2014 - academic.oup.com
Survival for patients with glioblastoma, the most common high-grade primary CNS tumor,
remains poor despite multiple therapeutic interventions including intensifying cytotoxic …
remains poor despite multiple therapeutic interventions including intensifying cytotoxic …
Therapeutic immune modulation against solid cancers with intratumoral poly-ICLC: a pilot trial
Purpose: Polyinosinic-polycytidylic acid-poly-l-lysine carboxymethylcellulose (poly-ICLC), a
synthetic double-stranded RNA complex, is a ligand for toll-like receptor-3 and MDA-5 that …
synthetic double-stranded RNA complex, is a ligand for toll-like receptor-3 and MDA-5 that …
Long-acting vaccine delivery systems
Bolus vaccines are often administered multiple times due to rapid clearance and reduced
transportation to draining lymph nodes resulting in inadequate activation of T and B …
transportation to draining lymph nodes resulting in inadequate activation of T and B …
[HTML][HTML] A phase II study of Tg4010 (Mva-Muc1-Il2) in association with chemotherapy in patients with stage III/IV Non-small cell lung cancer
Background TG4010 is a recombinant viral vector expressing both the tumor-associated
antigen MUC1 and Interleukine-2. This vector is based on the modified virus of Ankara, a …
antigen MUC1 and Interleukine-2. This vector is based on the modified virus of Ankara, a …