A reappraisal on metformin
T Adak, A Samadi, AZ Ünal, S Sabuncuoğlu - Regulatory Toxicology and …, 2018 - Elsevier
This review investigates the different biological effect of Metformin (MET) in different
conditions. MET is an oral antidiabetic drug used for the treatment of type 2 diabetes mellitus …
conditions. MET is an oral antidiabetic drug used for the treatment of type 2 diabetes mellitus …
[HTML][HTML] Effect of metformin on stem cells: Molecular mechanism and clinical prospect
LL Jiang, L Liu - World journal of stem cells, 2020 - ncbi.nlm.nih.gov
Metformin is a first-line medication for type II diabetes. Numerous studies have shown that
metformin not only has hypoglycemic effects, but also modulates many physiological and …
metformin not only has hypoglycemic effects, but also modulates many physiological and …
Metformin Decreases Reactive Oxygen Species, Enhances Osteogenic Properties of Adipose‐Derived Multipotent Mesenchymal Stem Cells In Vitro, and Increases Bone …
K Marycz, KA Tomaszewski, K Kornicka… - Oxidative medicine …, 2016 - Wiley Online Library
Due to its pleiotropic effects, the commonly used drug metformin has gained renewed
interest among medical researchers. While metformin is mainly used for the treatment of …
interest among medical researchers. While metformin is mainly used for the treatment of …
Metformin as a potential adjuvant antimicrobial agent against multidrug resistant bacteria
Introduction The continuous increase in the incidence of bacterial resistance to existing
antibiotics represents a worldwide health burden. A surrogate strategy to combat such crisis …
antibiotics represents a worldwide health burden. A surrogate strategy to combat such crisis …
Metformin‐induced MicroRNA‐34a‐3p downregulation alleviates senescence in human dental pulp stem cells by targeting CAB39 through the AMPK/mTOR signaling …
S Zhang, R Zhang, P Qiao, X Ma, R Lu… - Stem Cells …, 2021 - Wiley Online Library
Dental pulp stem cells (DPSCs) are ideal seed cells for the regeneration of dental tissues.
However, DPSC senescence restricts its clinical applications. Metformin (Met), a common …
However, DPSC senescence restricts its clinical applications. Metformin (Met), a common …
Biphasic effect of metformin on human cardiac energetics
L Emelyanova, X Bai, Y Yan, ZJ Bosnjak, D Kress… - Translational …, 2021 - Elsevier
Metformin is the first-line medication for treatment of type 2 diabetes and has been shown to
reduce heart damage and death. However, mechanisms by which metformin protects human …
reduce heart damage and death. However, mechanisms by which metformin protects human …
Antioxidant and anti-senescence effect of metformin on mouse olfactory ensheathing cells (mOECs) may be associated with increased brain-derived neurotrophic …
A Śmieszek, Z Stręk, K Kornicka, J Grzesiak… - International journal of …, 2017 - mdpi.com
Metformin, the popular anti-diabetic drug was shown to exert multiple biological effects. The
most recent metformin gained attention as an agent that mobilizes endogenous progenitor …
most recent metformin gained attention as an agent that mobilizes endogenous progenitor …
Metformin promotes osteogenic differentiation of adipose-derived stromal cells and exerts pro-osteogenic effect stimulating bone regeneration
A Śmieszek, KA Tomaszewski, K Kornicka… - Journal of clinical …, 2018 - mdpi.com
Metformin, the gold standard in type 2 diabetes treatment, is a drug with multi-faceted effects.
Currently, metformin has gained much attention as an agent that may find application in …
Currently, metformin has gained much attention as an agent that may find application in …
A story of metformin-butyrate synergism to control various pathological conditions as a consequence of gut microbiome modification: Genesis of a wonder drug?
K Maniar, A Moideen, A Mittal, A Patil… - Pharmacological …, 2017 - Elsevier
The most widely prescribed oral anti-diabetic agent today in the world today is a member of
the biguanide class of drugs called metformin. Apart from its use in diabetes, it is currently …
the biguanide class of drugs called metformin. Apart from its use in diabetes, it is currently …
Metformin improves stemness of human adipose-derived stem cells by downmodulation of mechanistic target of rapamycin (mTOR) and extracellular signal-regulated …
S Chinnapaka, KS Yang, Q Flowers, M Faisal… - Biomedicines, 2021 - mdpi.com
Adipose tissue plays an important role in regulating metabolic homeostasis by storing
excess fat and protecting other organs from lipotoxicity. Aging is associated with central fat …
excess fat and protecting other organs from lipotoxicity. Aging is associated with central fat …