The tight junction (TJ) is an essential component of the differentiated epithelial cell required
for polarised transport and intercellular integrity and signalling. Whilst much can be learnt …

Tight junction formation during development is critical for embryonic patterning and
organization. We consider mechanisms of junction biogenesis in cleaving mouse and …

Distinct mechanisms involving cell shape and mechanical force are known to influence the
rate and orientation of division in cultured cells. However, uncoupling the impact of shape …

We describe mesendoderm morphogenesis during gastrulation in the frog Xenopus laevis
and investigate the mechanics of these movements with tissue explants. When a dorsal …

MUC1 is a heterodimeric transmembrane glycoprotein that is overexpressed and aberrantly
glycosylated in ductal adenocarcinomas. Differential phosphorylation of the MUC1 …

Adhesion differences between cell populations are in principle a source of strong
morphogenetic forces promoting cell sorting, boundary formation and tissue positioning, and …

During amphibian gastrulation, presumptive endoderm is internalised as part of vegetal
rotation, a large-scale movement that encompasses the whole vegetal half of the embryo. It …

Although the transcriptional regulatory events triggered by Oct‐3/4 are well documented,
understanding the proteomic networks that mediate the diverse functions of this POU …

A simple epithelium forms a barrier between the outside and the inside of an organism, and
is the first organized multicellular tissue found in evolution. We examine the relationship …

Characterizing endogenous protein expression, interaction and function, this study identifies
in vivo interactions and competitive balance between N-cadherin and E-cadherin in …