Integrating single-cell and spatial transcriptomics to elucidate intercellular tissue dynamics
Single-cell RNA sequencing (scRNA-seq) identifies cell subpopulations within tissue but
does not capture their spatial distribution nor reveal local networks of intercellular …
does not capture their spatial distribution nor reveal local networks of intercellular …
[HTML][HTML] Single-cell multiomics: technologies and data analysis methods
Advances in single-cell isolation and barcoding technologies offer unprecedented
opportunities to profile DNA, mRNA, and proteins at a single-cell resolution. Recently, bulk …
opportunities to profile DNA, mRNA, and proteins at a single-cell resolution. Recently, bulk …
Spatial transcriptomics at subspot resolution with BayesSpace
Recent spatial gene expression technologies enable comprehensive measurement of
transcriptomic profiles while retaining spatial context. However, existing analysis methods …
transcriptomic profiles while retaining spatial context. However, existing analysis methods …
Human distal airways contain a multipotent secretory cell that can regenerate alveoli
The human lung differs substantially from its mouse counterpart, resulting in a distinct distal
airway architecture affected by disease pathology in chronic obstructive pulmonary disease …
airway architecture affected by disease pathology in chronic obstructive pulmonary disease …
Conservation and divergence of cortical cell organization in human and mouse revealed by MERFISH
The human cerebral cortex has tremendous cellular diversity. How different cell types are
organized in the human cortex and how cellular organization varies across species remain …
organized in the human cortex and how cellular organization varies across species remain …
Unified one-step multi-view spectral clustering
Multi-view spectral clustering, which exploits the complementary information among graphs
of diverse views to obtain superior clustering results, has attracted intensive attention …
of diverse views to obtain superior clustering results, has attracted intensive attention …
scAAGA: Single cell data analysis framework using asymmetric autoencoder with gene attention
R Meng, S Yin, J Sun, H Hu, Q Zhao - Computers in biology and medicine, 2023 - Elsevier
In recent years, single-cell RNA sequencing (scRNA-seq) has emerged as a powerful
technique for investigating cellular heterogeneity and structure. However, analyzing scRNA …
technique for investigating cellular heterogeneity and structure. However, analyzing scRNA …
[HTML][HTML] Inflammatory exposure drives long-lived impairment of hematopoietic stem cell self-renewal activity and accelerated aging
R Bogeska, AM Mikecin, P Kaschutnig, M Fawaz… - Cell stem cell, 2022 - cell.com
Hematopoietic stem cells (HSCs) mediate regeneration of the hematopoietic system
following injury, such as following infection or inflammation. These challenges impair HSC …
following injury, such as following infection or inflammation. These challenges impair HSC …
[HTML][HTML] Single-cell RNA sequencing demonstrates the molecular and cellular reprogramming of metastatic lung adenocarcinoma
N Kim, HK Kim, K Lee, Y Hong, JH Cho… - Nature …, 2020 - nature.com
Advanced metastatic cancer poses utmost clinical challenges and may present molecular
and cellular features distinct from an early-stage cancer. Herein, we present single-cell …
and cellular features distinct from an early-stage cancer. Herein, we present single-cell …
Tutorial: guidelines for the computational analysis of single-cell RNA sequencing data
Single-cell RNA sequencing (scRNA-seq) is a popular and powerful technology that allows
you to profile the whole transcriptome of a large number of individual cells. However, the …
you to profile the whole transcriptome of a large number of individual cells. However, the …