A metabolic handbook for the COVID-19 pandemic

JS Ayres - Nature metabolism, 2020 - nature.com
For infectious-disease outbreaks, clinical solutions typically focus on efficient pathogen
destruction. However, the COVID-19 pandemic provides a reminder that infectious diseases …

Oxidative stress and inflammation in acute and chronic lung injuries

FS Bezerra, M Lanzetti, RT Nesi, AC Nagato, CP Silva… - Antioxidants, 2023 - mdpi.com
Acute and chronic lung injuries are among the leading causes of mortality worldwide. Lung
injury can affect several components of the respiratory system, including the airways …

Pulmonary surfactant in adult ARDS: current perspectives and future directions

A Dushianthan, MPW Grocott, GS Murugan… - Diagnostics, 2023 - mdpi.com
Acute respiratory distress syndrome (ARDS) is a major cause of hypoxemic respiratory
failure in adults, leading to the requirement for mechanical ventilation and poorer outcomes …

HMGB1 as an extracellular pro-inflammatory cytokine: Implications for drug-induced organic damage

JY Yuan, L Guo, JT Ma, HJ Zhang, MX Xiao… - Cell Biology and …, 2024 - Springer
Drug-induced organic damage encompasses various intricate mechanisms, wherein
HMGB1, a non-histone chromosome-binding protein, assumes a significant role as a pivotal …

[HTML][HTML] Synthetic surfactant with a combined SP-B and SP-C analogue is efficient in rabbit models of adult and neonatal respiratory distress syndrome

P Mikolka, N Kronqvist, M Haegerstrand-Björkman… - Translational …, 2023 - Elsevier
Respiratory distress syndrome (RDS) in premature infants is caused by insufficient amounts
of endogenous lung surfactant and is efficiently treated with replacement therapy using …

Novel opportunities from bioimaging to understand the trafficking and maturation of intracellular pulmonary surfactant and its role in lung diseases

MJ Garcia, L Amarelle, L Malacrida, A Briva - Frontiers in Immunology, 2023 - frontiersin.org
Pulmonary surfactant (PS), a complex mixture of lipids and proteins, is essential for
maintaining proper lung function. It reduces surface tension in the alveoli, preventing …

SIRT1-related signaling pathways and their association with bronchopulmonary dysplasia

K Yang, W Dong - Frontiers in Medicine, 2021 - frontiersin.org
Bronchopulmonary dysplasia (BPD) is a chronic and debilitating disease that can exert
serious and overwhelming effects on the physical and mental health of premature infants …

Benefits and harms of increased inspiratory oxygen concentrations

LA Schwarte, P Schober, SA Loer - Current Opinion in …, 2019 - journals.lww.com
Benefits and harms of increased inspiratory oxygen concentra... : Current Opinion in
Anesthesiology Benefits and harms of increased inspiratory oxygen concentrations : Current …

N-acetylcysteine modulates redox imbalance and inflammation in macrophages and mice exposed to formaldehyde

EC Marcano-Gómez, ABF de Souza… - Free radical …, 2023 - Taylor & Francis
This study aimed to evaluate the protective role of N-acetylcysteine (NAC) in cells and mice
exposed to formaldehyde. For the in vitro study, J774A. 1 macrophages cells were incubated …

Impact of synthetic surfactant CHF5633 with SP‐B and SP‐C analogues on lung function and inflammation in rabbit model of acute respiratory distress syndrome

P Mikolka, T Curstedt, R Feinstein… - Physiological …, 2021 - Wiley Online Library
Acute respiratory distress syndrome (ARDS) is associated with diffuse inflammation, alveolar
epithelial damage, and leakage of plasma proteins into the alveolar space, which together …