Cellular senescence is the arrest of normal cell division. Oncogenic genes and oxidative
stress, which cause genomic DNA damage and generation of reactive oxygen species, lead …

Liver transplantation is the most common treatment for patients suffering from liver failure
that is caused by congenital diseases, infectious agents, and environmental factors. Despite …

In response to cellular stress or damage, proliferating cells can induce a specific program
that initiates a state of long-term cell-cycle arrest, termed cellular senescence. Accumulation …

Cellular senescence is a state of permanent growth arrest that plays an important role in
wound healing, tissue fibrosis, and tumor suppression. Despite senescent cells'(SnCs) …

Microphysiological systems (MPS), or “organ-on-a-chip” platforms, aim to recapitulate in vivo
physiology using small-scale in vitro tissue models of human physiology. While significant …

Radiation-induced pulmonary fibrosis (RIPF) is a chronic and progressive respiratory tract
disease characterized by collagen deposition. The pathogenesis of RIPF is still unclear …

Mesenchymal stem cells (MSCs) have emerged as promising cell-based therapies in the
treatment of degenerative and inflammatory conditions. However, despite accumulating …

With aging, a portion of cells, including mesenchymal stem cells (MSCs), become
senescent, and these senescent cells accumulate and promote various age-related …

Human pluripotent stem cells (hPSCs) are susceptible to numerical and structural
chromosomal alterations during long-term culture. We show that mitotic errors occur …

Age-associated structural and functional remodeling of the arterial wall produces a
productive environment for the initiation and progression of hypertension and …