Complement is a complex innate immune surveillance system, playing a key role in defense
against pathogens and in host homeostasis. The complement system is initiated by …

In 1969, Dr. Oscar Ratnoff, a pioneer in delineating the mechanisms by which coagulation is
activated and complement is regulated, wrote,“In the study of biological processes, the …

The parallel expression of activation products of the coagulation, fibrinolysis, and
complement systems has long been observed in both clinical and experimental settings …

Platelets contribute to processes beyond thrombus formation and may play a so far
underestimated role as an immune cell in various circumstances. This review outlines …

Platelets can be considered sentinels of vascular system due to their high number in the
circulation and to the range of functional immunoreceptors they express. Platelets express a …

Platelets are the main players in thrombosis and hemostasis; however they also play
important roles during inflammation and infection. Through their surface receptors, platelets …

Platelets play an essential role in maintaining homeostasis in the circulatory system after an
injury by forming a platelet thrombus, but they also occupy a central node in the …

Innate immunity is fundamental to our defense against microorganisms. Physiologically, the
intravascular innate immune system acts as a purging system that identifies and removes …

Tissue necrosis factor-α (TNF-α) and complement component 3 (C3) are two well-known pro-
inflammatory molecules. When TNF-α is upregulated, it contributes to changes in …

Coagulation and the immune system interact in several physiological and pathological
conditions, including tissue repair, host defense, and homeostatic maintenance. This …