Recent advances in omics technologies have led to unprecedented efforts characterizing
the molecular changes that underlie the development and progression of a wide array of …

Colorectal cancer (CRC) is the third most commonly diagnosed cancer in the United States,
and, even though 5–15% of the total CRC cases can be attributed to individual genetic …

Colorectal cancer (CRC) is a complex and widespread disease, currently ranked as the third
most frequent cancer worldwide. It is well known that the gut microbiota has an essential role …

DNA damage response is essential to human physiology. A broad spectrum of pathologies
are displayed by individuals carrying monoallelic or biallelic loss-of-function mutations in …

Background: Prostate cancer (PrCa) is one of the most common diseases to affect men
worldwide and among the leading causes of cancer-related death. The purpose of this study …

Colorectal cancer (CRC) is the third most common form of cancer. Diverse therapies such as
chemotherapy, immunotherapy and radiation have shown beneficial effects, but are limited …

Colorectal cancer (CRC) ranks third in the incidences of cancer morbidity and mortality
worldwide. CRC is rather heterogeneous with regard to molecular genetic characteristics …

DNA mismatch repair is a highly conserved DNA repair pathway. In humans, germline
mutations in hMSH2 or hMLH1, key components of mismatch repair, have been associated …

The stability and integrity of the human genome are maintained by the DNA damage repair
(DDR) system. Unrepaired DNA damage is a major source of potentially mutagenic lesions …

The microsatellite instability (MSI) pathway is one of the important mutational pathways that
play a critical role in colorectal carcinogenesis. About 15% of colorectal cancers (CRCs) are …