Chronic inflammation and immune responses are two core element that characterize the
tumor microenvironment. A large number of immune/inflammatory cells (including tumor …

It has become necessary to accept the clinical reality of therapeutic agents targeting the
cancer-associated immune system. In recent decades, several investigations have …

Background The acquisition of resistance to chemotherapy is a major hurdle in the
successful application of cancer therapy. Several anticancer approaches, including …

The aim of the manuscript is to discuss the influence of plant polyphenols in overcoming
multidrug resistance in four types of solid cancers (breast, colorectal, lung and prostate …

Chemoresistance contributes to poor survival and high relapse risk in acute myeloid
leukemia (AML). As a pro-inflammatory cytokine, interleukin-6 (IL-6) plays a vital role in the …

Recently, microRNAs (miRNAs) have shown to be potential therapeutic, diagnostic and
prognostic targets in disease therapy. These endogenous non-coding RNAs contribute to …

The limitations of current chemotherapeutic drugs are still a major issue in cancer treatment.
Thus, targeted multimodal therapeutic approaches need to be strategically developed to …

The difficulty of early diagnosis and the development of drug resistance are two major
barriers to the successful treatment of cancer. Autophagy plays a crucial role in several …

Two series of NSAIDs-EBS derivatives (5a-j and 9a-i) based on the hybridization of
nonsteroidal anti-inflammatory drugs (NSAIDs) skeleton and Ebselen moiety were …

Solid lipid nanoparticles (SLN) are used in various fields such as pharmaceutical, cosmetic,
and biomedical research and show promising results in delivering biomolecules. SLN …