Sensitive and selective detection of Pb 2+ is of great importance to both human health and
environmental protection. Here we propose a novel fluorescence anisotropy (FA) approach …

An expanded CUG repeat transcript (CUGexp) is the causative agent of myotonic dystrophy
type 1 (DM1) by sequestering muscleblind-like 1 protein (MBNL1), a regulator of alternative …

Fluorescence anisotropy is a homogeneous, sensitive, ratiometric, and real-time analytical
technology. However, it is a great challenge to produce a large fluorescence anisotropy …

Effective drug discovery and optimization can be accelerated by techniques capable of
deconvoluting the complexities often present in targeted biological systems. We report a …

Real time protein signaling in a complex medium may provide a promising way for high-
throughput protein analysis, but it is largely unmet due to the challenge of signal …

Single-molecule fluorescence measurements have been widely used to explore kinetics and
dynamics of biological systems. Among them, single-molecule imaging (SMI) is good at …

Oligonucleotide-based probes offer the highest spatial resolution, force sensitivity, and
molecular specificity for cellular tension sensing and have been developed to measure a …

Photoinduced electron transfer based fluorescence correlation spectroscopy (PET-FCS) is a
powerful tool to study biomolecular processes. However, some questions remain as to how …

Ochratoxin A (OTA) is a common mycotoxin with high carcinogenicity; therefore, it is crucial
to establish a simple, rapid, and sensitive method for its detection. In this study, we …

Nitrobenzoxadiazole (NBD)-incorporated naphthalene diimide derivatives were designed
and synthesized as candidates of antitumor agents with cytotoxicity against human …