High-frequency oscillations in epilepsy: what have we learned and what needs to be addressed
For the past 2 decades, high-frequency oscillations (HFOs) have been enthusiastically
studied by the epilepsy community. Emerging evidence shows that HFOs harbor great …
studied by the epilepsy community. Emerging evidence shows that HFOs harbor great …
Passive and active markers of cortical excitability in epilepsy
Electroencephalography (EEG) has been the primary diagnostic tool in clinical epilepsy for
nearly a century. Its review is performed using qualitative clinical methods that have …
nearly a century. Its review is performed using qualitative clinical methods that have …
Flexible, high‐resolution cortical arrays with large coverage capture microscale high‐frequency oscillations in patients with epilepsy
Objective Effective surgical treatment of drug‐resistant epilepsy depends on accurate
localization of the epileptogenic zone (EZ). High‐frequency oscillations (HFOs) are potential …
localization of the epileptogenic zone (EZ). High‐frequency oscillations (HFOs) are potential …
A neuromorphic spiking neural network detects epileptic high frequency oscillations in the scalp EEG
Abstract Interictal High Frequency Oscillations (HFO) are measurable in scalp EEG. This
development has aroused interest in investigating their potential as biomarkers of …
development has aroused interest in investigating their potential as biomarkers of …
Correcting for physiological ripples improves epileptic focus identification and outcome prediction
WJEM Zweiphenning, N von Ellenrieder, F Dubeau… - …, 2022 - Wiley Online Library
Objective The integration of high‐frequency oscillations (HFOs; ripples [80–250 Hz], fast
ripples [250–500 Hz]) in epilepsy evaluation is hampered by physiological HFOs, which …
ripples [250–500 Hz]) in epilepsy evaluation is hampered by physiological HFOs, which …
Graph theoretical measures of fast ripples support the epileptic network hypothesis
The epileptic network hypothesis and epileptogenic zone hypothesis are two theories of
ictogenesis. The network hypothesis posits that coordinated activity among interconnected …
ictogenesis. The network hypothesis posits that coordinated activity among interconnected …
[HTML][HTML] Delta oscillation coupled propagating fast ripples precede epileptiform discharges in patients with focal epilepsy
Epileptiform spikes are used to localize epileptogenic brain tissue. The mechanisms that
spontaneously trigger epileptiform discharges are not yet elucidated. Pathological fast ripple …
spontaneously trigger epileptiform discharges are not yet elucidated. Pathological fast ripple …
Graph theoretical measures of fast ripple networks improve the accuracy of post-operative seizure outcome prediction
Fast ripples (FR) are a biomarker of epileptogenic brain, but when larger portions of FR
generating regions are resected seizure freedom is not always achieved. To evaluate and …
generating regions are resected seizure freedom is not always achieved. To evaluate and …
[HTML][HTML] Chloride ion dysregulation in epileptogenic neuronal networks
SA Weiss - Neurobiology of Disease, 2023 - Elsevier
GABA is the major inhibitory neurotransmitter in the mature CNS. When GABA A receptors
are activated the membrane potential is driven towards hyperpolarization due to chloride …
are activated the membrane potential is driven towards hyperpolarization due to chloride …
Fast ripples reflect increased excitability that primes epileptiform spikes
The neuronal circuit disturbances that drive inter-ictal and ictal epileptiform discharges
remain elusive. Using a combination of extra-operative macro-electrode and micro-electrode …
remain elusive. Using a combination of extra-operative macro-electrode and micro-electrode …