Essential hypertension is a complex multifactorial disease process that involves the
interaction of multiple genes at various loci throughout the genome, and the influence of …

Angiotensin II and hypertension increase vascular oxidant stress. We examined how these
might affect expression of the extracellular superoxide dismutase (ecSOD), a major form of …

We determined the structure of mesenteric small arteries after chronic elevation and chronic
reduction of blood flow. In 6-wk-old rats, we ligated second-order side branches of every …

Arterial structural changes in experimental models of hypertension and restenosis differ
between vessel types and within vessels. Inspired by the diversity of short-term functional …

Structural adaptation of the blood vessel wall occurs in response to mechanical factors
related to blood pressure and flow. To elucidate the relative roles of pressure, flow, and …

Inhibition of cytochrome P-450 (CYP450) enzymes with cobalt chloride (CoCl2) prevented
hypertension, organ hypertrophy, and renal injury induced by DOCA and salt (1% NaCl) in …

Background Cellular aspects of remodelling have not been investigated fully in intact
vessels due to lack of appropriate methodology. Objective To determine the cellular …

Culture of vascular smooth muscle cells from small arteries of the rat kidney. Background In
contrast to arterioles, small arteries appear to be the preferential site of renal vascular …

The aim of the present study was to investigate the level of regulation of the contractile
endothelin ETB receptor which appears spontaneously after organ culture of vascular …

The stroke-prone spontaneously hypertensive rat (SHRSP) is a strain with high incidence of
cerebrovascular accidents increased by salt-rich diet and decreased by calcium-antagonist …