Abstract Cisplatin [cis-DDP, cis-diamminedichloroplatinum (II)] is a potent anticancer drug
that has been used successfully to treat tumors of the head, neck, lungs, and genitourinary …

Since the serendipitous discovery of the biological action of platinum coordination
complexes in 1965 (Rosenberg et al., 1965), cis-diamminedichloroplatinum (cis-DDP) has …

The classic coordination complex cis-diamminedichloroplatinum (II), 1 cis-DDP or cisplatin,
has been the subject of much recent attention because of its bene-ficial effects in the …

In 1965, an experiment designed to study the effects of electromagnetic fields on bacterial
growth revealed that the normal, rod-like shape of the bacteria could be altered when a low …

The discovery that cis-diamminedichloroplatinum (II)(cis-DDP) has clinically useful antitumor
properties and can form platinum blues spawned an extensive investigation of its chemistry …

This tutorial review summarises B-DNA structure and metallomolecule binding modes and
illustrates some DNA structures induced by molecules containing metallic cations. The …

Substitution reactions with biologic nucleophiles appear to govern the antitumor and toxic
properties of platinum complexes. In this paper we have characterized the reactions of …

After the discovery of cisplatin, many metal compounds were investigated for the therapy of
diseases, especially cancer. The high therapeutic potential of metal-based compounds is …

Diethyldithiocarbamate (DDTC) has been shown to protect against the toxicity of cis-
diamminedichloroplatinum (II)(DDP) without inhibition of antitumor effect. We report here that …

The interaction of two experimental ruthenium (III)-containing antitumor complexes—Na
[trans-RuCl4 (DMSO)(Im)](NAMI) and dichloro (1, 2-propylendiaminetetraacetate) ruthenium …