Regioselectivity in the ring opening of non-activated aziridines
In this critical review, the ring opening of non-activated 2-substituted aziridinesvia
intermediate aziridinium salts will be dealt with. Emphasis will be put on the relationship …
intermediate aziridinium salts will be dealt with. Emphasis will be put on the relationship …
Hypervalent iodine: a powerful electrophile for asymmetric α-functionalization of carbonyl compounds
DQ Dong, SH Hao, ZL Wang, C Chen - Organic & Biomolecular …, 2014 - pubs.rsc.org
Environmentally friendly hypervalent iodine reagents are unusually effective promoters of
asymmetric α-functionalization of carbonyl compounds. By using hypervalent iodine …
asymmetric α-functionalization of carbonyl compounds. By using hypervalent iodine …
Synthesis of Z-Alkenes from Rh(I)-Catalyzed Olefin Isomerization of β,γ-Unsaturated Ketones
LG Zhuo, ZK Yao, ZX Yu - Organic Letters, 2013 - ACS Publications
Developing olefin isomerization reactions to reach kinetically controlled Z-alkenes is
challenging because formation of trans-alkenes is thermodynamically favored under the …
challenging because formation of trans-alkenes is thermodynamically favored under the …
Preparation of porous organic polymers containing N or P atoms and their application in hydroformylation of 1-octene
W Jiang, J Li, M Wu, L He, G Zhou, Z Wang - Fuel, 2023 - Elsevier
Three kinds of porous organic polymers (POPs) containing N or P atoms were prepared,
named N-POP, P-POP, and N+ P-POP respectively and used as the supports for Rh …
named N-POP, P-POP, and N+ P-POP respectively and used as the supports for Rh …
Regio‐and Enantioselective Formal Hydroamination of Enamines for the Synthesis of 1, 2‐Diamines
L Yu, P Somfai - Angewandte Chemie, 2019 - Wiley Online Library
The asymmetric formal hydroamination of enamines using a CuH catalyst is reported. The
method provides a straightforward and efficient approach to the synthesis of chiral 1, 2 …
method provides a straightforward and efficient approach to the synthesis of chiral 1, 2 …
Highly substituted cyclopentane–CMP conjugates as potent sialyltransferase inhibitors
W Li, Y Niu, DC Xiong, X Cao… - Journal of Medicinal …, 2015 - ACS Publications
Sialylconjugates on cell surfaces are involved in many biological events such as cellular
recognition, signal transduction, and immune response. It has been reported that aberrant …
recognition, signal transduction, and immune response. It has been reported that aberrant …
Exploration of aziridine-and β-lactam-based hybrids as both bioactive substances and synthetic intermediates in medicinal chemistry
S Vandekerckhove, M D'hooghe - Bioorganic & medicinal chemistry, 2013 - Elsevier
The concept of pharmacophore hybridization is attracting an increasing interest from
medicinal chemists. Whereas the main motivation for the application of this methodology …
medicinal chemists. Whereas the main motivation for the application of this methodology …
Application of Regio‐and Stereoselective Functional Group Transformations of Chiral Aziridine‐2‐carboxylates
HJ Ha, JH Jung, WK Lee - Asian Journal of Organic Chemistry, 2014 - Wiley Online Library
Chiral aziridine‐2‐carboxylates have two important functional groups, the carboxylate group
and aziridine ring, that are useful for synthetic purposes. As both (2R)‐and (2S)‐aziridine‐2 …
and aziridine ring, that are useful for synthetic purposes. As both (2R)‐and (2S)‐aziridine‐2 …
Opposite regiospecific ring opening of 2-(cyanomethyl) aziridines by hydrogen bromide and benzyl bromide: experimental study and theoretical rationalization
S Catak, M D'hooghe, T Verstraelen… - The Journal of …, 2010 - ACS Publications
Ring opening of 1-arylmethyl-2-(cyanomethyl) aziridines with HBr afforded 3-(arylmethyl)
amino-4-bromobutyronitriles via regiospecific ring opening at the unsubstituted aziridine …
amino-4-bromobutyronitriles via regiospecific ring opening at the unsubstituted aziridine …
Systematic Study of Halide‐Induced Ring Opening of 2‐Substituted Aziridinium Salts and Theoretical Rationalization of the Reaction Pathways
M D'hooghe, S Catak, S Stanković, M Waroquier, Y Kim… - 2010 - Wiley Online Library
The ring‐opening reactions of 2‐alkyl‐substituted 1, 1‐bis (arylmethyl)‐and 1‐methyl‐1‐(1‐
phenylethyl) aziridinium salts with fluoride, chloride, bromide and iodide in acetonitrile have …
phenylethyl) aziridinium salts with fluoride, chloride, bromide and iodide in acetonitrile have …