Promising natural products in new drug design, development, and therapy for skin disorders: An overview of scientific evidence and understanding their mechanism of …

NA Mohd Zaid, M Sekar, SR Bonam… - Drug design …, 2023 - Taylor & Francis
The skin is the largest organ in the human body, composed of the epidermis and the dermis.
It provides protection and acts as a barrier against external menaces like allergens …

[HTML][HTML] Harnessing role of sesamol and its nanoformulations against neurodegenerative diseases

N Singh, S Vishwas, A Kaur, H Kaur, V Kakoty… - Biomedicine & …, 2023 - Elsevier
Sesamol is a lignan of sesame seeds and a natural phenolic molecule that has emerged as
a useful medical agent. Sesamol is a non-toxic phytoconstituent, which exerts certain …

Recent updates on functionalized silicon quantum-dot-based nanoagents for biomedical applications

D Yang, Z Cui, Z Wen, Z Piao, H He, X Wei… - ACS Materials …, 2023 - ACS Publications
Silicon nanomaterials are one of the most representative inorganic nanomedicines in
therapeutic biomedicine. Silicon quantum dots (Si QDs) have aroused wide attention in the …

Therapeutic potential of natural compounds in neurodegenerative diseases: insights from clinical trials

S Andrade, D Nunes, M Dabur, MJ Ramalho… - Pharmaceutics, 2023 - mdpi.com
Neurodegenerative diseases are caused by the gradual loss of neurons' function. These
neurological illnesses remain incurable, and current medicines only alleviate the symptoms …

Natural product-based pharmacological studies for neurological disorders

V Puri, N Kanojia, A Sharma, K Huanbutta… - Frontiers in …, 2022 - frontiersin.org
Central nervous system (CNS) disorders and diseases are expected to rise sharply in the
coming years, partly because of the world's aging population. Medicines for the treatment of …

Flight for fish in drug discovery: a review of zebrafish-based screening of molecules

SN Dash, L Patnaik - Biology Letters, 2023 - royalsocietypublishing.org
Human disease and biological practices are modelled in zebrafish (Danio rerio) at various
phases of drug development as well as toxicity evaluation. The zebrafish is ideal for in vivo …

Pathogenesis of Huntington's disease: an emphasis on molecular pathways and prevention by natural remedies

Z Irfan, S Khanam, V Karmakar, SM Firdous… - Brain Sciences, 2022 - mdpi.com
Background: Huntington's disease is an inherited autosomal dominant trait neuro-
degenerative disorder caused by changes (mutations) of a gene called huntingtin (htt) that is …

Role of sugar osmolytes and their nano-counterparts as inhibitors in protein fibrillation

D Alam, F Naaz, A Islam, M Sardar, T Ahmad - Journal of Molecular Liquids, 2023 - Elsevier
Protein aggregation is responsible for various human diseases, ie Alzheimer's, Parkinson's,
Huntington's as well as cataract. Finding molecular drugs which could prevent protein …

Inhibiting protein aggregation by small molecule-based colloidal nanoparticles

K Debnath, AK Sarkar, NR Jana… - Accounts of materials …, 2021 - ACS Publications
Conspectus Protein aggregation is associated with different human diseases such as
Alzheimer's, Huntington's, Parkinson's, diabetes type II, and cataracts. Currently no effective …

Natural compounds as lactate dehydrogenase inhibitors: Potential therapeutics for lactate dehydrogenase inhibitors-related diseases

JH Han, EJ Lee, W Park, KT Ha… - Frontiers in …, 2023 - frontiersin.org
Lactate dehydrogenase (LDH) is a crucial enzyme involved in energy metabolism and
present in various cells throughout the body. Its diverse physiological functions encompass …