Hot-melt extrusion (HME) is a promising technology for the production of new chemical
entities in the developmental pipeline and for improving products already on the market. In …

In this era of competition quality has been given prime magnitude; failure to meet such
quality allied goals produces massive shift of company in share of market. In this context …

Population balance modeling is undergoing phenomenal growth in its applications, and this
growth is accompanied by multifarious reviews. This review aims to fortify the model's …

Wet granulation is a very important unit operation that finds applications in many industries
mainly pharmaceutical and chemical industries. Various granulation technologies in batch …

In this study, a novel mechanistic model for a wet granulation process is presented,
combining the techniques of population balance modeling and discrete element methods to …

This paper presents a generic framework of Model Driven Design (MDD) with its application
for a twin screw granulation process using a mechanistic-based population balance model …

Granulation, a size enlargement technique to form agglomerates of primary particles, has
proven to be effective in the production of solid dosage forms. Numerous granulation …

Quality is the lifeline for all pharmaceuticals. Process analytical technology (PAT),
introduced by FDA in 2004, providing significant opportunities for improving pharmaceutical …

Twin-screw granulation is an emerging continuous granulation technique in the
pharmaceutical industry. The flexibility in process settings such as the binder addition …

High-shear wet granulation is a complex process that, in turn, makes scale-up a challenging
task. Scale-up of high-shear wet granulation process has been studied extensively in the …