HIV-associated neurocognitive disorder—pathogenesis and prospects for treatment
In the past two decades, several advancements have improved the care of HIV-infected
individuals. Most importantly, the development and deployment of combination antiretroviral …
individuals. Most importantly, the development and deployment of combination antiretroviral …
Changing clinical phenotypes of HIV-associated neurocognitive disorders
N Sacktor - Journal of neurovirology, 2018 - Springer
HIV-associated neurocognitive disorder (HAND) remains a common cause of cognitive
impairment and persists in 15–55% of HIV+ individuals in the combination antiretroviral …
impairment and persists in 15–55% of HIV+ individuals in the combination antiretroviral …
Hallmarks of metabolic reprogramming and their role in viral pathogenesis
Metabolic reprogramming is a hallmark of cancer and has proven to be critical in viral
infections. Metabolic reprogramming provides the cell with energy and biomass for large …
infections. Metabolic reprogramming provides the cell with energy and biomass for large …
HIV infection and latency induce a unique metabolic signature in human macrophages
P Castellano, L Prevedel, S Valdebenito… - Scientific reports, 2019 - nature.com
Currently, a major barrier to curing HIV infection is the generation of tissue-associated, non-
replicating, long-lasting viral reservoirs that are refractory to therapy and can be reactivated …
replicating, long-lasting viral reservoirs that are refractory to therapy and can be reactivated …
Proteomic analysis of cerebrospinal fluid extracellular vesicles reveals synaptic injury, inflammation, and stress response markers in HIV patients with cognitive …
Abstract Background Extracellular vesicles (EVs) are nano-sized particles present in most
body fluids including cerebrospinal fluid (CSF). Little is known about CSF EV proteins in …
body fluids including cerebrospinal fluid (CSF). Little is known about CSF EV proteins in …
Persistent Biofluid Small-Molecule Alterations Induced by Trypanosoma cruzi Infection Are Not Restored by Parasite Elimination
DA Dean, J Roach, R Ulrich vonBargen… - ACS Infectious …, 2023 - ACS Publications
Chagas disease (CD), caused by Trypanosoma cruzi (T. cruzi) protozoa, is a complicated
parasitic illness with inadequate medical measures for diagnosing infection and monitoring …
parasitic illness with inadequate medical measures for diagnosing infection and monitoring …
Chronic low-level expression of HIV-1 Tat promotes a neurodegenerative phenotype with aging
The widespread use of combinational antiretroviral therapies (cART) in developed countries
has changed the course of Human Immunodeficiency Virus (HIV) infection from an almost …
has changed the course of Human Immunodeficiency Virus (HIV) infection from an almost …
Integrative metabolomics to identify molecular signatures of responses to vaccines and infections
Approaches to the identification of metabolites have progressed from early biochemical
pathway evaluation to modern high-dimensional metabolomics, a powerful tool to identify …
pathway evaluation to modern high-dimensional metabolomics, a powerful tool to identify …
Laboratory diagnosis of central nervous system infection
T He, S Kaplan, M Kamboj, YW Tang - Current infectious disease reports, 2016 - Springer
Central nervous system (CNS) infections are potentially life threatening if not diagnosed and
treated early. The initial clinical presentations of many CNS infections are non-specific …
treated early. The initial clinical presentations of many CNS infections are non-specific …
Examining relationships between metabolism and persistent inflammation in HIV patients on antiretroviral therapy
D Ahmed, D Roy, E Cassol - Mediators of inflammation, 2018 - Wiley Online Library
With the advent of antiretroviral therapy (ART), HIV‐infected individuals are now living
longer and healthier lives. However, ART does not completely restore health and treated …
longer and healthier lives. However, ART does not completely restore health and treated …