A systematic review of the evidence for deprescribing interventions among older people living with frailty

K Ibrahim, NJ Cox, JM Stevenson, S Lim, SDS Fraser… - BMC geriatrics, 2021 - Springer
Background Older people living with frailty are often exposed to polypharmacy and potential
harm from medications. Targeted deprescribing in this population represents an important …

Interventions to improve the appropriate use of polypharmacy for older people

A Rankin, CA Cadogan, SM Patterson… - Cochrane Database …, 2018 - cochranelibrary.com
Background Inappropriate polypharmacy is a particular concern in older people and is
associated with negative health outcomes. Choosing the best interventions to improve …

Medication review interventions to reduce hospital readmissions in older people

L Dautzenberg, L Bretagne, HL Koek… - Journal of the …, 2021 - Wiley Online Library
Objective To assess the efficacy of medication review as an isolated intervention and with
several co‐interventions for preventing hospital readmissions in older adults. Methods Ovid …

Effects of a clinical medication review focused on personal goals, quality of life, and health problems in older persons with polypharmacy: a randomised controlled trial …

S Verdoorn, HF Kwint, JW Blom, J Gussekloo… - Plos …, 2019 - journals.plos.org
Background Clinical medication reviews (CMRs) are increasingly performed in older
persons with multimorbidity and polypharmacy to reduce drug-related problems (DRPs) …

International core outcome set for clinical trials of medication review in multi-morbid older patients with polypharmacy

JB Beuscart, W Knol, S Cullinan, C Schneider… - BMC medicine, 2018 - Springer
Background Comparisons of clinical trial findings in systematic reviews can be hindered by
the heterogeneity of the outcomes reported. Moreover, the outcomes that matter most to …

A modified Delphi study to determine the level of consensus across the European Union on the structures, processes and desired outcomes of the management of …

D Stewart, K Gibson-Smith, K MacLure, A Mair… - PloS one, 2017 - journals.plos.org
Background Inappropriate use of multiple medicines (inappropriate polypharmacy) is a
major challenge in older people with consequences of increased prevalence and severity of …

Process, impact and outcomes of medication review in Australian residential aged care facilities: A systematic review

EYH Chen, KN Wang, JK Sluggett… - … journal on ageing, 2019 - Wiley Online Library
Objective To systematically review literature reporting processes, impact and outcomes of
medication review and reconciliation in Australian residential aged care facilities (RACF s) …

Reducing the anticholinergic and sedative load in older patients on polypharmacy by pharmacist-led medication review: a randomised controlled trial

HG van der Meer, H Wouters, LG Pont, K Taxis - BMJ open, 2018 - bmjopen.bmj.com
Objective To evaluate if a pharmacist-led medication review is effective at reducing the
anticholinergic/sedative load, as measured by the Drug Burden Index (DBI). Design …

Effect of a patient-centred deprescribing procedure in older multimorbid patients in Swiss primary care-A cluster-randomised clinical trial

S Zechmann, O Senn, F Valeri, S Essig, C Merlo… - BMC geriatrics, 2020 - Springer
Background Management of patients with polypharmacy is challenging, and evidence for
beneficial effects of deprescribing interventions is mixed. This study aimed to investigate …

Polypharmacy and deprescribing: challenging the old and embracing the new

LK O'Donnell, K Ibrahim - BMC geriatrics, 2022 - Springer
People are living longer, and the World Health Organisation predicts that by 2050, 22% of
the world's population will be aged 60 years or older [1]. A common consequence of ageing …