Advances in molecular biology, microfluidics and bioinformatics have empowered the study
of thousands or even millions of individual cells from malignant tumours at the single-cell …

Single-cell transcriptomics has broadened our understanding of cellular diversity and gene
expression dynamics in healthy and diseased tissues. Recently, spatial transcriptomics has …

Molecular characterization of cell types using single-cell transcriptome sequencing is
revolutionizing cell biology and enabling new insights into the physiology of human organs …

With advances in sequencing and instrument technology, bioinformatics analysis is being
applied to batches of massive cells at single-cell resolution. High-throughput single-cell …

The immune system is highly complex and distributed throughout an organism, with
hundreds to thousands of cell states existing in parallel with diverse molecular pathways …

Cells from the same individual share common genetic and environmental backgrounds and
are not statistically independent; therefore, they are subsamples or pseudoreplicates. Thus …

Single-cell assay for transposase-accessible chromatin by sequencing (scATAC-seq) has
emerged as a powerful tool for dissecting regulatory landscapes and cellular heterogeneity …

The tumor immune microenvironment is a main contributor to cancer progression and a
promising therapeutic target for oncology. However, immune microenvironments vary …

T cells are at the center of cancer immunology because of their ability to recognize mutations
in tumor cells and directly mediate cancer cell killing. Immunotherapies to rejuvenate …

The rapid adoption of single-cell technologies has created an opportunity to build single-cell
'atlases' integrating diverse datasets across many laboratories. Such atlases can serve as a …