The Wnt pathway is central to a host of developmental and disease-related processes. The
remarkable conservation of this intercellular signaling cascade throughout metazoan …

Mutation-induced activation of WNT–β-catenin signalling is a frequent driver event in human
cancer. Sustained WNT–β-catenin pathway activation endows cancer cells with sustained …

The Wnt-β-catenin signaling pathway is an evolutionarily conserved cell-cell communication
system that is important for stem cell renewal, cell proliferation and cell differentiation both …

TP53 is the most frequently mutated gene in cancer, yet these mutations remain
therapeutically non-actionable. Major challenges in drugging p53 mutations include …

WNT signaling is an elaborate and complex collection of signal transduction pathways
mediated by multiple signaling molecules. WNT signaling is critically important for …

Wnts are lipid-modified morphogens that play critical roles in development principally
through engagement of Frizzled receptors. The 3.25 angstrom structure of Xenopus Wnt8 …

Frizzled and LRP5/6 are Wnt receptors that upon activation lead to stabilization of
cytoplasmic β-catenin. In this study, we review the current knowledge of these two families of …

Wnt genes and components of Wnt signalling pathways have been implicated in a wide
spectrum of important biological phenomena, ranging from early organismal development to …

Wnt signaling plays critical roles in development of various organs and pathogenesis of
many diseases, and augmented Wnt signaling has recently been implicated in mammalian …

The low-density lipoprotein (LDL) receptor-related protein 2 (LRP2 or megalin) is
representative of the phylogenetically conserved subfamily of giant LDL receptor-related …