Folate being an important vitamin of B Complex group in our diet plays an important role not
only in the synthesis of DNA but also in the maintenance of methylation reactions in the …

Acute lymphoblastic leukemia (ALL) is diagnosed in 3000 to 4000 persons in the United
States each year; two thirds of them are children. 1, 2 The current rate of cure of nearly 80 …

Acute lymphoblastic leukemia (ALL), a clonal expansion of hematopoietic blasts, is a highly
heterogeneous disease comprising many entities for which distinct treatment strategies are …

We conducted a genome-wide association study (GWAS) on multiple sclerosis (MS)
susceptibility in German cohorts with 4888 cases and 10,395 controls. In addition to …

Past analyses examining the relationship between genetic variation in the 5, 10-
methylenetetrahydrofolate reductase (MTHFR) gene and psychiatric disorders have …

Megaloblastic anaemia is usually due to deficiency of vitamin B12 (B12, cobalamin) or
folate. Both deficiencies impair DNA synthesis by reducing the supply of deoxythymidine …

To evaluate the contribution of candidate gene association studies to the understanding of
genetic susceptibility to childhood acute lymphoblastic leukemia we conducted a systematic …

Enzymatic methylation catalyzed by methyltransferases has a significant impact on many
human biochemical reactions. As the second most ubiquitous cofactor in humans, S …

Studies of childhood leukemia and the potential etiologic role of genetic variation in folate
metabolism have produced conflicting findings and have often been based on small …

Objective. Although methotrexate (MTX) is the most widely prescribed drug in juvenile
idiopathic arthritis (JIA), 30% of patients fail to respond to it. To individualize treatment …