Cisplatin for cancer therapy and overcoming chemoresistance

R Ranasinghe, ML Mathai, A Zulli - Heliyon, 2022 - cell.com
Cisplatin spearheads the anticancer chemotherapeutics in present-day use although acute
toxicity is its primary impediment factor. Among a plethora of experimental medications, a …

Advances in diagnosis and treatment of testicular cancer

M Chovanec, L Cheng - bmj, 2022 - bmj.com
Testicular cancer is a curable cancer. The success of physicians in curing the disease is
underpinned by multidisciplinary advances. Cisplatin-based combination chemotherapy and …

Surgery in early metastatic seminoma: a phase II trial of retroperitoneal lymph node dissection for testicular seminoma with limited retroperitoneal lymphadenopathy

S Daneshmand, C Cary, T Masterson… - Journal of Clinical …, 2023 - ascopubs.org
PURPOSE The long-term toxicities of chemotherapy and radiotherapy can represent a
significant burden to testicular cancer survivors. Retroperitoneal lymph node dissection …

[HTML][HTML] Risk-adapted modulation through de-intensification of cancer treatments: an ESMO classification

D Trapani, MA Franzoi, HJ Burstein, LA Carey… - Annals of …, 2022 - Elsevier
Background The landscape of clinical trials testing risk-adapted modulations of cancer
treatments is complex. Multiple trial designs, endpoints, and thresholds for non-inferiority …

[HTML][HTML] Molecular biomarkers with potential clinical application in testicular cancer

J Lobo, AM Acosta, GJ Netto - Modern Pathology, 2023 - Elsevier
Testicular germ cell tumors (TGCTs) and sex cord-stromal tumors (SCSTs) are the most
common testicular neoplasms. The morphological spectrum of such tumors is wide, with …

MiRNA biomarkers in cancers of the male reproductive system: are we approaching clinical application?

V Constâncio, NT Tavares, R Henrique… - …, 2023 - Wiley Online Library
Background Specific cancer types face specific clinical management challenges. Owing to
their stability, robustness and fast, easy and cost‐effective detection, microRNAs (miRNAs) …

Systemic immune-inflammation index and mortality in testicular cancer: a systematic review and meta-analysis

FE Salazar-Valdivia, VA Valdez-Cornejo… - Diagnostics, 2023 - mdpi.com
The systemic immune-inflammation index (SIII) is a marker studied in multiple types of
urologic cancer. This systematic review evaluates the association between SIII values with …

Testicular cancer: biology to bedside

J King, N Adra, LH Einhorn - Cancer research, 2021 - AACR
Testicular cancer is the first solid tumor with a remarkably high cure rate. This success was
only made possible through collaborative efforts of basic and clinical research. Most patients …

Cardiovascular disease in testicular cancer survivors: identification of risk factors and impact on quality of life

S Lubberts, HJ Groot, R de Wit, S Mulder… - Journal of Clinical …, 2023 - ascopubs.org
PURPOSE Testicular cancer (TC) treatment is clearly associated with cardiovascular
morbidity and mortality. To enable development of preventive strategies for cardiovascular …

An exploration of testicular cancer survivors' experience of ejaculatory dysfunction following retroperitoneal lymph node dissection—a sub-study of the PREPARE …

C Conduit, AD Hutchinson, M Leonard… - Journal of Cancer …, 2023 - Springer
Purpose Ejaculatory dysfunction secondary to retrograde ejaculation or anejaculation is a
complication of retroperitoneal lymph node dissection (RPLND) for survivors of testicular …