An original evidence review examined screening and diagnosis of hereditary nonpolyposis
colorectal cancer (HNPCC) and the subsequent outcomes in a population of newly …

The aim of this article is to present updated guidelines for the use of serum, tissue and faecal
markers in colorectal cancer (CRC). Lack of specificity and sensitivity preclude the use of all …

Background: Although high-risk mutations in identified major susceptibility genes (DNA
mismatch repair genes and MUTYH) account for some familial aggregation of colorectal …

Purpose Lynch syndrome due to pathogenic variants in the DNA mismatch repair genes
MLH1, MSH2, and MSH6 is predominantly associated with colorectal and endometrial …

The utility of immunohistochemical detection of DNA mismatch repair (MMR) protein in
screening colorectal tumors for hereditary nonpolyposis colorectal cancer (HNPCC) …

Background & Aims: Although the clinical phenotype of Lynch syndrome (also known as
hereditary nonpolyposis colorectal cancer) has been well described, little is known about …

Background Germline mutations in MSH6 account for 10%–20% of Lynch syndrome
colorectal cancers caused by hereditary DNA mismatch repair gene mutations. Because …

Colorectal and Other Cancer Risks for Carriers and Noncarriers From Families With a DNA
Mismatch Repair Gene Mutation: A Prospective Cohort Study - PMC Back to Top Skip to main …

Lynch syndrome (hereditary non-polyposis colorectal cancer) is characterised by the
development of colorectal cancer, endometrial cancer and various other cancers, and is …

ABSTRACT We studied 17,576 members of 166 MLH 1 and 224 MSH 2 mutation‐carrying
families from the C olon C ancer F amily R egistry. Average cumulative risks of colorectal …