Alzheimer's disease (AD) is a chronic neurodegenerative brain disorder characterized by
memory impairment, dementia, and oxidative stress in elderly people. Currently, only a few …

There is a large unmet medical need to develop disease-modifying treatment options for
individuals with age-related degenerative diseases of the central nervous system. The …

The molecular code that controls synapse formation and maintenance in vivo has remained
quite sparse. Here, we identify that the secreted protein Adamtsl3 functions as critical …

Adult neural plasticity engages mechanisms that change synapse structure and function, yet
many of the underlying events bear a striking similarity to processes that occur during the …

Background The search for biomarkers of bipolar disorder (BD), including epigenetic
alterations, has heavily relied on peripheral investigations that do not necessarily reflect …

The severe acute respiratory syndrome-related coronavirus 2 (SARS-CoV-2) and the
сoronavirus disease 2019 (COVID-19) have become a global health threat. At the height of …

Neurotoxic side effects of chemotherapy include deficits in attention, memory, and executive
functioning. Currently, there are no FDA-approved therapies. In mice, cisplatin causes long …

During neuronal development, dynamic filopodia emerge from dendrites and mature into
functional dendritic spines during synaptogenesis. Dendritic filopodia and spines respond to …

The receptor deleted in colorectal cancer (DCC) and its ligand netrin-1 are essential for
axon guidance during development and are expressed by neurons in the mature brain …

Netrin-1 is a neural guidance factor that regulates migration and positioning of neural crest-
derived cells during embryonic development. Depending on the type of Netrin-1 receptor …