Conventional anticancer chemotherapy has been historically thought to act through direct
killing of tumor cells. This concept stems from the fact that cytotoxic drugs interfere with DNA …

The predominant definition of apoptosis considers that the elimination of the apoptosing cell
is by heterolytic degradation following phagocytosis by an assisting scavenger …

In children, cancer probably arises from a combination of inherited genetic mutations and
genetic alterations that are acquired during the rapid cellular expansion that occurs during …

Tumors evolve mechanisms to escape immune control by a process called immune editing,
which provides a selective pressure in the tumor microenvironment that could lead to …

Background High intensity focused ultrasound (HIFU) is an emerging non-invasive treatment
modality for localized treatment of cancers. While current clinical strategies employ HIFU …

Subclinical doses of Paclitaxel (PTX) given 1day prior to a HER-2/neu (neu)-targeted,
granulocyte–macrophage colony stimulating factor (GM-CSF)-secreting whole-cell vaccine …

It has long been known that immunization with a protein by itself is often not sufficient to
stimulate immunity, and may instead induce tolerance. To elicit productive immune …

Despite a concerted effort on the part of scientists and clinicians, cancer remains one of the
leading causes of death in industrialized countries. Furthermore, in spite of stunning …

Chemotherapy and radiotherapy have been extensively used to eradicate cancer based on
their direct cytocidal effects on rapidly proliferating tumor cells. Accumulating evidence …

The effects of high-intensity focused ultrasound (HIFU) on the release of endogenous
danger signals from tumor cells and subsequent activation of antigen-presenting cells …