Genome sequencing projects have provided researchers with a complete inventory of the
predicted proteins produced by eukaryotic and prokaryotic organisms. Assignment of …

Photoaffinity labeling has a longstanding history as a powerful biochemical technique.
However, photoaffinity labeling has significantly evolved over the past decade principally …

A number of metalloproteins are important medicinal targets for conditions ranging from
pathogenic infections to cancer. Many but not all of these metalloproteins contain a zinc (II) …

Cells reprogram their transcriptome in response to stress, such as heat shock. In free-living
bacteria, the transcriptomic reprogramming is mediated by increased DNA-binding activity of …

As arguably the most successful parasite, Chlamydia is an obligate intracellular bacterium
replicating inside a vacuole of eukaryotic host cells. The chlamydial vacuole does not fuse …

Chlamydia trachomatis (CT) causes the most prevalent sexually transmitted bacterial
disease in the United States. The lack of drug selectivity is one of the main challenges of the …

Esophageal cancer is a complex gastrointestinal malignancy with an extremely poor
outcome. Approximately 80% of cases of this malignancy in Asian countries including India …

Peptide deformylase (PDF) is among the few antibacterial targets against which novel
synthetic inhibitors derived from rationally designed, mechanism-based libraries have …

Mer receptor tyrosine kinase (Mer) signaling plays a central role in the intrinsic inhibition of
the inflammatory response to Toll-like receptor activation. Previously, we found that lung Mer …

Understanding the ways in which pathogens invade and neutralize their hosts is of great
interest from both an academic and a clinical perspective. However, in many cases genetic …