[HTML][HTML] Gut microbiota dysbiosis, oxidative stress, inflammation, and epigenetic alterations in metabolic diseases

H Mostafavi Abdolmaleky, JR Zhou - Antioxidants, 2024 - mdpi.com
Gut dysbiosis, resulting from an imbalance in the gut microbiome, can induce excessive
production of reactive oxygen species (ROS), leading to inflammation, DNA damage …

Epigenetics and beyond: targeting histone methylation to treat type 2 diabetes mellitus

Y Yang, Y Luan, Q Feng, X Chen, B Qin… - Frontiers in …, 2022 - frontiersin.org
Diabetes mellitus is a global public health challenge with high morbidity. Type 2 diabetes
mellitus (T2DM) accounts for 90% of the global prevalence of diabetes. T2DM is featured by …

The gut microbial regulation of epigenetic modification from a metabolic perspective

X Lin, H Han, N Wang, C Wang, M Qi, J Wang… - International Journal of …, 2024 - mdpi.com
Obesity is a global health challenge that has received increasing attention in contemporary
research. The gut microbiota has been implicated in the development of obesity, primarily …

Glucagon-like peptide 1 and fibroblast growth factor-21 in non-alcoholic steatohepatitis: An experimental to clinical perspective

P Yadav, A Khurana, JS Bhatti, R Weiskirchen… - Pharmacological …, 2022 - Elsevier
Non-alcoholic steatohepatitis (NASH) is a progressive form of Non-alcoholic fatty liver
disease (NAFLD), which slowly progresses toward cirrhosis and finally leads to the …

Effects of Lactoferrin and Lactobacillus Supplementation on Immune Function, Oxidative Stress, and Gut Microbiota in Kittens

H Dong, W Wang, Q Chen, X Chang, L Wang, S Chen… - Animals, 2024 - mdpi.com
Simple Summary Kittens often suffer from weak immune systems, making them more prone
to infections and diseases, which can severely affect their health and growth. This study …

Vincamine, an active constituent of Vinca rosea ameliorates experimentally induced acute lung injury in Swiss albino mice through modulation of Nrf-2/NF-κB …

AP Renushe, AK Banothu, KK Bharani, L Mekala… - International …, 2022 - Elsevier
Acute lung injury (ALI) or acute respiratory distress syndrome (ARDS) is one of the leading
pulmonary inflammatory disorders causing significant morbidity and mortality. Vincamine is …

Lactobacillus paracasei CCFM1223 Protects against Lipopolysaccharide-Induced Acute Liver Injury in Mice by Regulating the “Gut–Liver” Axis

W Guo, B Mao, X Tang, Q Zhang, J Zhao, S Cui… - Microorganisms, 2022 - mdpi.com
Background: Lactobacillus paracasei CCFM1223, a probiotic previously isolated from the
healthy people's intestine, exerts the beneficial influence of preventing the development of …

Tropolone derivative hinokitiol ameliorates cerulein-induced acute pancreatitis in mice

Y Chelpuri, S Pabbathi, GR Alla, RK Yadala… - International …, 2022 - Elsevier
Hinokitiol is a natural bio-active tropolone derivative with promising antioxidant and anti-
inflammatory properties. This study was conducted to evaluate the ameliorative effects of …

Lactobacillus rhamnosus supplementation ameliorates high fat diet-induced epigenetic alterations and prevents its intergenerational inheritance

VG Sheth, N Sharma, SW Kabeer, K Tikoo - Life Sciences, 2022 - Elsevier
Aim Multiple studies have reported the epigenetic inheritance of parental metabolic traits
could increase the risk of developing metabolic disorders in offsprings. L. rhamnosus (LR) …

[HTML][HTML] Roles of lysine methylation in glucose and lipid metabolism: Functions, regulatory mechanisms, and therapeutic implications

Z Wang, H Liu - Biomolecules, 2024 - mdpi.com
Glucose and lipid metabolism are essential energy sources for the body. Dysregulation in
these metabolic pathways is a significant risk factor for numerous acute and chronic …