Varicocele is recognized as the leading cause of male infertility because it can impair
spermatogenesis through several distinct pathophysiological mechanisms. Current …

Mammalian spermatogenesis is a complex biological process occurring in the seminiferous
tubules in the testis. This process represents a delicate balance between cell proliferation …

Varicocele is the most common and treatable cause of male infertility. Studies of a rat
experimental left varicocele model and human testicular biopsy samples have shown the …

Reactive nitrogen species (RNS) is a subset of free oxygen radicals called reactive oxygen
species (ROS). Physiological levels of ROS are necessary to maintain the reproductive …

Reactive nitrogen species (RNS), like reactive oxygen species (ROS), are useful for
sustaining reproductive processes such as cell signaling, the regulation of hormonal …

Background Varicocoele (VCL), one of the main causes of male subfertility, negatively
affects testicular function. Due to limited access to human testicular tissue, animal model …

Cisplatin (CIS) is widely applied for its antihematological malignancies properties and as
antisolid tumors drugs. However, it could cause testicular damage related with oxidative …

Background Varicocoele is a common risk factor associated with reduced male fertility
potential. The current understanding of varicocoele pathophysiology does not completely …

Background Low concentrations of nitric oxide (NO) are necessary for the biology and
physiology of spermatozoa, but high levels of NO are toxic and have negative effects on …

Background The present study was done to investigate the ameliorative effect of silymarin
(SMN) and celecoxib (CEL) on varicocele (VCL)-induced detrimental impact in testicular …