Advances in PET imaging of cancer
J Schwenck, D Sonanini, JM Cotton… - Nature Reviews …, 2023 - nature.com
Molecular imaging has experienced enormous advancements in the areas of imaging
technology, imaging probe and contrast development, and data quality, as well as machine …
technology, imaging probe and contrast development, and data quality, as well as machine …
Nanobodies: next generation of cancer diagnostics and therapeutics
The development of targeted medicine has greatly expanded treatment options and spurred
new research avenues in cancer therapeutics, with monoclonal antibodies (mAbs) emerging …
new research avenues in cancer therapeutics, with monoclonal antibodies (mAbs) emerging …
Tumor-associated macrophages: from basic research to clinical application
L Yang, Y Zhang - Journal of hematology & oncology, 2017 - Springer
The fact that various immune cells, including macrophages, can be found in tumor tissues
has long been known. With the introduction of concept that macrophages differentiate into a …
has long been known. With the introduction of concept that macrophages differentiate into a …
Progress in tumor-associated macrophage (TAM)-targeted therapeutics
C Ngambenjawong, HH Gustafson, SH Pun - Advanced drug delivery …, 2017 - Elsevier
As an essential innate immune population for maintaining body homeostasis and warding
off foreign pathogens, macrophages display high plasticity and perform diverse supportive …
off foreign pathogens, macrophages display high plasticity and perform diverse supportive …
Nanobodies and nanobody-based human heavy chain antibodies as antitumor therapeutics
P Bannas, J Hambach, F Koch-Nolte - Frontiers in immunology, 2017 - frontiersin.org
Monoclonal antibodies have revolutionized cancer therapy. However, delivery to tumor cells
in vivo is hampered by the large size (150 kDa) of conventional antibodies. The minimal …
in vivo is hampered by the large size (150 kDa) of conventional antibodies. The minimal …
Relevance of immune cell and tumor microenvironment imaging in the new era of immunotherapy
F Galli, JV Aguilera, B Palermo, SN Markovic… - Journal of experimental …, 2020 - Springer
Tumor-infiltrating immune cells play a key role against cancer. However, malignant cells are
able to evade the immune response and establish a very complex balance in which different …
able to evade the immune response and establish a very complex balance in which different …
Plasticity of myeloid-derived suppressor cells in cancer
E Tcyganov, J Mastio, E Chen, DI Gabrilovich - Current opinion in …, 2018 - Elsevier
Highlights•Myeloid-derived suppressor cells (MDSC) are critically important for regulation of
immune responses in cancer.•MDSC have distinct features separating them from neutrophils …
immune responses in cancer.•MDSC have distinct features separating them from neutrophils …
Insights from transgenic mouse models of PyMT-induced breast cancer: recapitulating human breast cancer progression in vivo
Breast cancer is associated with the second highest cancer-associated deaths worldwide.
Therefore, understanding the key events that determine breast cancer progression …
Therefore, understanding the key events that determine breast cancer progression …
Bioconjugated manganese dioxide nanoparticles enhance chemotherapy response by priming tumor-associated macrophages toward M1-like phenotype and …
Hypoxia promotes not only the invasiveness of tumor cells, but also chemoresistance in
cancer. Tumor associated macrophages (TAMs) residing at the site of hypoxic region of …
cancer. Tumor associated macrophages (TAMs) residing at the site of hypoxic region of …
Nanobodies as therapeutics: big opportunities for small antibodies
S Steeland, RE Vandenbroucke, C Libert - Drug discovery today, 2016 - Elsevier
Highlights•Nanobodies (Nbs) are camelid-derived single-domain antibodies.•Nbs have
powerful binding and inhibitory capacity with great therapeutic potential.•Nbs are used in …
powerful binding and inhibitory capacity with great therapeutic potential.•Nbs are used in …