Alzheimer's disease (AD) is the most common form of dementia worldwide. β-amyloid
peptide (Aβ) is currently assumed to be the main cause of synaptic dysfunction and cognitive …

Among other mechanisms, oxidative stress has been postulated to play an important role in
the rate of ageing. Oxidative damage contributes to the hallmarks of ageing and essential …

Oxidative stress is induced by an imbalanced redox states, involving either excessive
generation of reactive oxygen species (ROS) or dysfunction of the antioxidant system. The …

Astaxanthin is a natural C40 carotenoid with numerous reported biological functions, most of
them associated with its antioxidant and anti-inflammatory activity, standing out from other …

The purpose of our article is to assess the current understanding of Indian spice, curcumin,
against amyloid-ß (Aß)-induced toxicity in Alzheimer's disease (AD) pathogenesis. Natural …

Background Cognitive impairment, including dementia, is a major health concern with the
increasing aging population. Preventive measures to delay cognitive decline are of utmost …

Accumulating evidence in mice models of accelerated senescence indicates a rescuing role
of ascorbic acid in premature aging. Supplementation of ascorbic acid appeared to halt cell …

The concept of mild cognitive impairment (MCI) as an intermediate state between normal
cognition and dementia entered into the vernacular of geriatric medicine more than 30 years …

Free radicals and other so-called 'reactive species' are constantly produced in the brain in
vivo. Some arise by 'accidents of chemistry', an example of which may be the leakage of …

The current recommended dietary allowance (RDA) for vitamin C for adult nonsmoking men
and women is 60 mg/d, which is based on a mean requirement of 46 mg/d to prevent the …