Microglia are the brain's resident macrophages, which guide various developmental
processes crucial for brain maturation, activity, and plasticity. Microglial progenitors enter the …

The proper organization of cells and tissues is essential for their functionalization in living
organisms. To create materials that mimic natural structures, researchers have developed …

Spatial transcriptomics approaches have substantially advanced our capacity to detect the
spatial distribution of RNA transcripts in tissues, yet it remains challenging to characterize …

Spatially charting molecular cell types at single-cell resolution across the 3D volume is
critical for illustrating the molecular basis of brain anatomy and functions. Single-cell RNA …

A fundamental interest in developmental neuroscience lies in the ability to map the complete
single-cell lineages within the brain. To this end, we developed a CRISPR editing-based …

The rapid development of spatial transcriptomics allows the measurement of RNA
abundance at a high spatial resolution, making it possible to simultaneously profile gene …

Proper neural progenitor behavior in conjunction with orderly vasculature formation is
fundamental to the development of the neocortex. However, the mechanisms coordinating …

Spatial transcriptomics technologies enable researchers to accurately quantify and localize
messenger ribonucleic acid (mRNA) transcripts at a high resolution while preserving their …

Single-cell transcriptomics has broadened our understanding of cellular diversity and gene
expression dynamics in healthy and diseased tissues. Recently, spatial transcriptomics has …

Debate remains around the anatomical origins of specific brain cell subtypes and lineage
relationships within the human forebrain,,,,,–. Thus, direct observation in the mature human …