The cannabis derivative marijuana is the most widely used recreational drug in the Western
world and is consumed by an estimated 83 million individuals (∼ 3% of the world …

The endocannabinoid system (ECS) is composed of two G protein-coupled receptors
(GPCRs), the cannabinoid CB1 and CB2 receptors, and the two main endogenous lipid …

Endocannabinoids are lipid mediators able to bind to and activate cannabinoid receptors,
the primary molecular targets responsible for the pharmacological effects of the Δ9 …

Cells of the immune system and the central nervous system are capable of interacting with
each other. The former cell populations respond to infection, tissue injury and trauma by …

N-Acylethanolamine acid amidase (NAAA) is an N-terminal cysteine hydrolase primarily
found in the endosomal–lysosomal compartment of innate and adaptive immune cells …

Fatty acid ethanolamides (FAEs) and endocannabinoids (ECs) have been shown to
alleviate pain and inflammation, regulate motility and appetite, and produce anticancer …

Highlights•PEA is an anti-inflammatory and neuroprotective compound.•Pharmacological
tools are available to control PEA levels via FAAH and NAAA inhibition.•FAAH and NAAA …

N-Palmitoylethanolamine or palmitoylethanolamide (PEA) is an anti-inflammatory
compound that was recently shown to exert peroxisome proliferator-activated receptor-α …

Macrophages are multi-faceted phagocytic effector cells that derive from circulating
monocytes and undergo differentiation in target tissues to regulate key aspects of the …

Fatty acid ethanolamides such as palmitoylethanolamide (PEA) and oleoylethanolamide
(OEA) are lipid-derived mediators that potently inhibit pain and inflammation by ligating type …