Free radicals are generated in the brain, as well as in other organs, and their production is
proportional to the brain activity. Due to its low antioxidant capacity, the brain is particularly …

In a state of balance between oxidants and antioxidants, free radicals play an advantageous
role of “redox messengers”. In a state of oxidative stress, they trigger a cascade of events …

Epilepsy is a disease characterized by recurrent, episodic, and transient central nervous
system (CNS) dysfunction resulting from an excessive synchronous discharge of brain …

Epilepsy is a common neurological disorder which affects patients physically and mentally
and causes a real burden for the patient, family and society both medically and …

Epilepsy is one of most common chronic neurological disorders, and the antiseizure
medications developed by targeting neurocentric mechanisms have not effectively reduced …

Despite recent advances in understanding the causes of epilepsy, especially the genetic,
comprehending the biological mechanisms that lead to the epileptic phenotype remains …

Neuronal dysfunction due to iron accumulation in conjunction with reactive oxygen species
(ROS) could represent an important, yet underappreciated, component of the epileptogenic …

Though succinate accumulation is associated with reactive oxygen species (ROS)
production and neuronal injury, which play critical roles in epilepsy, it is unclear whether …

Seizures often originate in epileptogenic foci. Between seizures (interictally), these foci and
some of the surrounding tissue often show low signals with 18fluorodeoxyglucose (FDG) …

The infiltration of immune cells is observed in the epileptogenic zone; however, the
relationship between epilepsy and regulatory T cells (Tregs) remains only partially …