Genomic changes that drive cancer initiation and progression contribute to the co-evolution
of the adjacent stroma. The nature of the stromal reprogramming involves differential DNA …

Abstract Fibronectin 1 (FN1) is involved in the occurrence and development of various
tumors and is upregulated in multiple cancer types. FN1 has been demonstrated to promote …

Cribriform prostate cancer, found in both invasive cribriform carcinoma (ICC) and intraductal
carcinoma (IDC), is an aggressive histological subtype that is associated with progression to …

We identified distinct senescence-related molecular subtypes and critical genes among
prostate cancer (PCa) patients undergoing radical prostatectomy (RP) or radical …

Introduction: Over the last decade, the improvement in molecular techniques and the
acquisition of genomic information has transformed and increased the quality of patient care …

During the last ten years, many research results have been referring to a particular type of
cancer-associated fibroblasts associated with poor prognosis, invasiveness, metastasis and …

The molecular mechanisms underlying lethal castration-resistant prostate cancer remain
poorly understood, with intratumoral heterogeneity a likely contributing factor. To examine …

The assessment of the risk of biochemical recurrence (BCR) is critical in the management of
males with prostate cancer (PC). Over the past decades, a comprehensive effort has been …

Prostate cancer (PCa) is a hormone-dependent tumor characterized by an extremely
heterogeneous prognosis. Despite recent advances in partially uncovering some of the …

Background The dual upregulation of TOP2A and EZH2 gene expression has been
proposed as a biomarker for recurrence in prostate cancer patients to be treated with radical …