The cardiac ryanodine receptor-Ca2+ release channel (RyR2) is an essential sarcoplasmic
reticulum (SR) transmembrane protein that plays a central role in excitation–contraction …

In many cell types the intracellular Ca2+ store performs a central role in the regulation of the
cytosolic Ca2+ concentration ([Ca2+] c), the elevation of which triggers diverse and …

Ryanodine-sensitive Ca2 release channels, also known as the ryanodine receptors (RyRs),
2 are homotetramers of an 550-kDa subunit (Fig. 1) that are resident proteins of intracellular …

The anti-apoptotic B-cell lymphoma-2 (Bcl-2) protein not only counteracts apoptosis at the
mitochondria by scaffolding pro-apoptotic Bcl-2-family members, but also acts at the …

The 12kDa FK506-binding protein (FKBP12) constitutively binds to the calcium release
channel RyR1. Removal of FKBP12 using FK506 or rapamycin causes an increased open …

The ryanodine receptor (RyR) calcium release channel functions as a redox sensor that is
sensitive to channel modulators. The FK506-binding protein (FKBP) is an important …

The FK506-binding proteins (FKBP12 and FKBP12. 6; also known as FKBP1A and FKBP1B,
respectively) are accessory subunits of the ryanodine receptor (RyR) Ca2+ release channel …

Catecholaminergic polymorphic ventricular tachycardia (CPVT) is associated with mutations
in the cardiac ryanodine receptor (RyR2). These result in stress‐induced ventricular …

Mutations in the cardiac ryanodine receptor Ca2+ release channel (RyR2) can cause deadly
ventricular arrhythmias and atrial fibrillation (AF). The RyR2-P2328S mutation produces …

The 12-and 12.6-kDa FK506-binding proteins, FKBP12 (12-kDa FK506-binding protein) and
FKBP12. 6 (12.6-kDa FK506-binding protein), have been implicated in the binding to and …