Therapeutic potential of targeting oxidative stress in diabetic cardiomyopathy

NJ Byrne, NS Rajasekaran, ED Abel… - Free Radical Biology and …, 2021 - Elsevier
Even in the absence of coronary artery disease and hypertension, diabetes mellitus (DM)
may increase the risk for heart failure development. This risk evolves from functional and …

[HTML][HTML] Polysulfide-mediated sulfhydration of SIRT1 prevents diabetic nephropathy by suppressing phosphorylation and acetylation of p65 NF-κB and STAT3

HJ Sun, SP Xiong, X Cao, L Cao, MY Zhu, ZY Wu… - Redox biology, 2021 - Elsevier
Diabetic kidney disease is known as a major cause of chronic kidney disease and end stage
renal disease. Polysulfides, a class of chemical agents with a chain of sulfur atoms, are …

[HTML][HTML] An updated insight into molecular mechanism of hydrogen sulfide in cardiomyopathy and myocardial ischemia/reperfusion injury under diabetes

HJ Sun, ZY Wu, XW Nie, XY Wang… - Frontiers in …, 2021 - frontiersin.org
Cardiovascular diseases are the most common complications of diabetes, and diabetic
cardiomyopathy is a major cause of people death in diabetes. Molecular, transcriptional …

[HTML][HTML] Metrnl ameliorates diabetic cardiomyopathy via inactivation of cGAS/STING signaling dependent on LKB1/AMPK/ULK1-mediated autophagy

QB Lu, Y Ding, Y Liu, ZC Wang, YJ Wu, KM Niu… - Journal of advanced …, 2023 - Elsevier
Abstract Introduction Meteorin-like hormone (Metrnl) is ubiquitously expressed in skeletal
muscle, heart, and adipose with beneficial roles in obesity, insulin resistance, and …

Poly (pentahydropyrimidine)‐Based Hybrid Hydrogel with Synergistic Antibacterial and Pro‐Angiogenic Ability for the Therapy of Diabetic Foot Ulcers

W Li, H Chen, J Cai, M Wang, X Zhou… - Advanced Functional …, 2023 - Wiley Online Library
Bacterial infection and impaired angiogenesis make the treatment of diabetic foot ulcers
(DFU) extremely challenging. Cationic polymers are expected to treat infected wounds due …

Fucoxanthin ameliorated myocardial fibrosis in STZ-induced diabetic rats and cell hypertrophy in HG-induced H9c2 cells by alleviating oxidative stress and restoring …

D Zheng, L Chen, G Li, L Jin, Q Wei, Z Liu, G Yang… - Food & Function, 2022 - pubs.rsc.org
Diabetic cardiomyopathy (DCM) is one of the leading causes of death in diabetic patients,
and is accompanied by increased oxidative stress and mitochondrial dysfunction …

Chicoric acid ameliorates sepsis-induced cardiomyopathy via regulating macrophage metabolism reprogramming

HJ Sun, GL Zheng, ZC Wang, Y Liu, N Bao, PX Xiao… - Phytomedicine, 2024 - Elsevier
Background Sepsis-related cardiac dysfunction is believed to be a primary cause of high
morbidity and mortality. Metabolic reprogramming is closely linked to NLRP3 inflammasome …

Expanding the frontiers of guardian antioxidant selenoproteins in cardiovascular pathophysiology

T Angelone, C Rocca, V Lionetti, C Penna… - Antioxidants & Redox …, 2024 - liebertpub.com
Significance: Physiological levels of reactive oxygen and nitrogen species (ROS/RNS)
function as fundamental messengers for many cellular and developmental processes in the …

Roles of circular RNAs in diabetic complications: from molecular mechanisms to therapeutic potential

JR Zhang, HJ Sun - Gene, 2020 - Elsevier
Diabetes is characterized by changed homeostasis of blood glucose levels, which is
associated with various complications, including cardiomyopathy, atherosclerosis …

Cardioprotective and anti-inflammatory effects of Caveolin 1 in experimental diabetic cardiomyopathy

W Gong, Q Jiao, J Yuan, H Luo, Y Liu, Y Zhang… - Clinical …, 2023 - portlandpress.com
Previous studies of the Caveolin 1 (Cav1) protein and caveolae, which are lipid raft
structures found on the plasma membranes of certain cells, are associated with fat …